ZFIN ID: ZDB-GENE-090814-1
Gene Name: transcription factor 4
Gene Symbol: tcf4    Nomenclature History

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Previous Name: tcf4l

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have protein dimerization activity. Involved in brain development and lens development in camera-type eye. Used to study Pitt-Hopkins syndrome. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Is expressed in several structures, including brain; digestive system; notochord; pectoral fin bud; and retina. Orthologous to human TCF4 (transcription factor 4).
Genome Resources: Alliance (1),  Gene:100526651 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
wi702 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-tcf4 1
MO1-tcf4 N/A 1
MO2-tcf4 N/A 1
MO3-tcf4 N/A 1
DISEASE ASSOCIATED WITH tcf4 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 3 613267
Pitt-Hopkins syndrome Alliance Pitt-Hopkins syndrome 610954
DISEASE ASSOCIATED WITH tcf4 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
Pitt-Hopkins syndrome AB/TU + MO1-tcf4 + MO2-tcf4 standard conditions Brockschmidt et al., 2011
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tcf4 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:XM_021468942 (1)
Genomic GenBank:CABZ01086137 (1) 26067 bp
Select Tool
Polypeptide UniProtKB:E2J8V4 (1) 677 aa
Sequence Information (all 46)
ORTHOLOGY for tcf4 ( Chr: 21 )
CITATIONS (18)