Gene

tfeb

ID

ZDB-GENE-090807-3

Name

transcription factor EB

Symbol

tfeb Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within central nervous system myelination. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including digestive system; head; immature eye; mesoderm; and pronephros. Orthologous to human TFEB (transcription factor EB).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

9 figures from 7 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Meireles et al., 2018
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tfeb Human Ortholog

No data available

Associated With tfeb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Domain	IPR021802	MiT/TFE transcription factors, C-terminal
Domain	IPR024098	Transcription factor EB, bHLHzip domain
Domain	IPR031867	MiT/TFE transcription factors, N-terminal
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	MiT/TFE transcription factors, C-terminal	MiT/TFE transcription factors, N-terminal	Myc-type, basic helix-loop-helix (bHLH) domain	Transcription factor EB, bHLHzip domain
UniProtKB:E7FEM8 InterPro	491
UniProtKB:A0A8M9Q799 InterPro	433
UniProtKB:A0A2R8RRI1 InterPro	493
UniProtKB:A0A8M2BK54 InterPro	325
UniProtKB:G5CIM3 InterPro	493
UniProtKB:A0A8M2BK61 InterPro	327

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tfeb-201 (1) Ensembl	Ensembl	6,145 nt	Select Tool ZFIN BLAST
mRNA	tfeb-202 (1) Ensembl	Ensembl	899 nt	Select Tool ZFIN BLAST
mRNA	tfeb-203 (1) Ensembl	Ensembl	870 nt	Select Tool ZFIN BLAST
mRNA	tfeb-204 (1) Ensembl	Ensembl	6,284 nt	Select Tool ZFIN BLAST
mRNA	tfeb-205 (1) Ensembl	Ensembl	6,190 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations