Gene
itga3a
- ID
- ZDB-GENE-090805-3
- Name
- integrin, alpha 3a
- Symbol
- itga3a Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be part of integrin complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa. Orthologous to human ITGA3 (integrin subunit alpha 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zhu et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Epidermolysis bullosa, junctional 7, with interstitial lung disease and nephrotic syndrome | 614748 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018184 | Integrin alpha chain, C-terminal cytoplasmic region, conserved site |
| Domain | IPR013649 | Integrin alpha, first immunoglubulin-like domain |
| Domain | IPR048285 | Integrin alpha, second immunoglobulin-like domain |
| Domain | IPR048286 | Integrin alpha, third immunoglobulin-like domain |
| Family | IPR000413 | Integrin alpha chain |
| Homologous_superfamily | IPR028994 | Integrin alpha, N-terminal |
| Homologous_superfamily | IPR032695 | Integrin domain superfamily |
| Repeat | IPR013517 | FG-GAP repeat |
| Repeat | IPR013519 | Integrin alpha beta-propellor |
Domain Details Per Protein
| Protein | Length | FG-GAP repeat | Integrin alpha beta-propellor | Integrin alpha chain | Integrin alpha chain, C-terminal cytoplasmic region, conserved site | Integrin alpha, first immunoglubulin-like domain | Integrin alpha, N-terminal | Integrin alpha, second immunoglobulin-like domain | Integrin alpha, third immunoglobulin-like domain | Integrin domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9QA60
|
1053 | |||||||||
|
UniProtKB:A0A8M6YWS7
|
1073 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
itga3a-201
(1)
|
Ensembl | 3,680 nt | ||
| mRNA |
itga3a-202
(1)
|
Ensembl | 2,748 nt |
Interactions and Pathways
No data available
Plasmids
No data available