Gene
atoh1c
- ID
- ZDB-GENE-090805-1
- Name
- atonal bHLH transcription factor 1c
- Symbol
- atoh1c Nomenclature History
- Previous Names
-
- Zath1c (1)
- Type
- protein_coding_gene
- Location
- Chr: 12 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and E-box binding activity. Acts upstream of or within cerebellar granule cell differentiation. Predicted to be active in nucleus. Is expressed in midbrain hindbrain boundary neural rod; midbrain hindbrain boundary neural tube; and nervous system. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 89. Orthologous to human ATOH1 (atonal bHLH transcription factor 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 11 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Kidwell et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| fh367 | Allele with one deletion | Unknown | Premature Stop | TALEN |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal dominant nonsyndromic deafness 89 | Alliance | ?Deafness, autosomal dominant 89 | 620284 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Basic helix-loop-helix transcription factors | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain |
|---|---|---|---|---|
|
UniProtKB:A0A8M9Q9E7
|
204 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
atoh1c-201
(1)
|
Ensembl | 776 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
| Construct | Regulatory Region | Coding Sequence | Species | Tg Lines | Citations |
|---|---|---|---|---|---|
| TgBAC(atoh1c:GAL4FF) |
|
| 1 | (2) |
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| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-257J3 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_003199570 (1) | 783 nt | ||
| Genomic | GenBank:CR792429 (2) | 163868 nt | ||
| Polypeptide | UniProtKB:A0A8M9Q9E7 (1) | 204 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | ATOH1 | 4 | Amino acid sequence comparison (1) |
- Itoh, T., Uehara, M., Yura, S., Wang, J.C., Fujii, Y., Nakanishi, A., Shimizu, T., Hibi, M. (2024) Foxp- and Skor-family proteins control differentiation of Purkinje cells from Ptf1a and Neurogenin1-expressing progenitors in zebrafish. Development (Cambridge, England). 151(7):
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Itoh, T., Inoue, S., Sun, X., Kusuda, R., Hibi, M., Shimizu, T. (2021) Cfdp1 controls the cell cycle and neural differentiation in the zebrafish cerebellum and retina. Developmental Dynamics : an official publication of the American Association of Anatomists. 250(11):1618-1633
- Belzunce, I., Belmonte-Mateos, C., Pujades, C. (2020) The interplay of atoh1 genes in the lower rhombic lip during hindbrain morphogenesis. PLoS One. 15:e0228225
- Zhu, J., Wang, H.T., Chen, Y.R., Yan, L.Y., Han, Y.Y., Liu, L.Y., Cao, Y., Liu, Z.Z., Xu, H.A. (2020) The Joubert Syndrome Gene arl13b is Critical for Early Cerebellar Development in Zebrafish. Neuroscience Bulletin. 36(9):1023-1034
- Kidwell, C.U., Su, C.Y., Hibi, M., Moens, C.B. (2018) Multiple zebrafish atoh1 genes specify a diversity of neuronal types in the zebrafish cerebellum. Developmental Biology. 438(1):44-56
- Marín-Juez, R., Rovira, M., Crespo, D., van der Vaart, M., Spaink, H.P., Planas, J.V. (2015) GLUT2-mediated glucose uptake and availability are required for embryonic brain development in zebrafish. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 35(1):74-85
- Flasse, L.C., Pirson, J.L., Stern, D.G., Von Berg, V., Manfroid, I., Peers, B., and Voz, M.L. (2013) Ascl1b and Neurod1, instead of Neurog3, control pancreatic endocrine cell fate in zebrafish. BMC Biology. 11(1):78
- Kaslin, J., Kroehne, V., Benato, F., Argenton, F., and Brand, M. (2013) Development and specification of cerebellar stem and progenitor cells in zebrafish: from embryo to adult. Neural Development. 8(1):9
- Chaplin, N., Tendeng, C., and Wingate, R.J. (2010) Absence of an external germinal layer in zebrafish and shark reveals a distinct, anamniote ground plan of cerebellum development. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30(8):3048-3057
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