Gene

megf8

ID
ZDB-GENE-090730-1
Name
multiple EGF-like-domains 8
Symbol
megf8 Nomenclature History
Previous Names
  • fb77g03
  • si:dkey-108f8.4
  • wu:fb77g03 (1)
  • zgc:158741 (1)
Type
protein_coding_gene
Location
Chr: 16 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and calcium ion binding activity. Involved in left/right pattern formation. Acts upstream of or within cell migration involved in gastrulation; determination of left/right symmetry; and epiboly involved in gastrulation with mouth forming second. Predicted to be located in membrane. Predicted to be integral component of membrane. Used to study Carpenter syndrome. Human ortholog(s) of this gene implicated in Carpenter syndrome. Orthologous to human MEGF8 (multiple EGF like domains 8).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With megf8 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Carpenter syndrome Alliance Carpenter syndrome 2 614976
Associated With megf8 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018097 EGF-like calcium-binding, conserved site
Domain IPR000742 EGF-like domain
Domain IPR000859 CUB domain
Domain IPR001881 EGF-like calcium-binding domain
Domain IPR002049 Laminin EGF domain
Domain IPR005225 Small GTP-binding protein domain
Domain IPR016201 PSI domain
Domain IPR024731 EGF domain
Family IPR001806 Small GTPase
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011043 Galactose oxidase/kelch, beta-propeller
Homologous_superfamily IPR015915 Kelch-type beta propeller
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR035914 Spermadhesin, CUB domain superfamily
PTM IPR000152 EGF-type aspartate/asparagine hydroxylation site
Repeat IPR002165 Plexin repeat
Domain Details Per Protein
Protein Length CUB domain EGF domain EGF-like calcium-binding, conserved site EGF-like calcium-binding domain EGF-like domain EGF-type aspartate/asparagine hydroxylation site Galactose oxidase/kelch, beta-propeller Growth factor receptor cysteine-rich domain superfamily Kelch-type beta propeller Laminin EGF domain Plexin repeat P-loop containing nucleoside triphosphate hydrolase PSI domain Small GTPase Small GTP-binding protein domain Spermadhesin, CUB domain superfamily
UniProtKB:A1L2A5 184
UniProtKB:F1QBZ9 2870
UniProtKB:A0A0R4IQQ8 173
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations