Gene
upf2
- ID
- ZDB-GENE-090715-1
- Name
- UPF2 regulator of nonsense mediated mRNA decay
- Symbol
- upf2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 4 Mapping Details/Browsers
- Description
- Predicted to enable RNA binding activity. Acts upstream of or within chordate embryonic development. Predicted to be located in cytoplasm. Orthologous to human UPF2 (UPF2 regulator of nonsense mediated mRNA decay).
- Genome Resources
-
- Alliance (1)
- Gene:569006 (1)
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Wittkopp et al., 2009
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wittkopp et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | MIF4G-like, type 3 | Nonsense-mediated mRNA decay protein Nmd2/UPF2 |
|---|---|---|---|---|
|
UniProtKB:A0A8M6YZM1
|
583 |
1 - 1 of 1
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_017355122 (1) | 1752 nt | ||
| Genomic | GenBank:CABZ01068469 (1) | 4143 nt | ||
| Polypeptide | UniProtKB:A0A8M6YZM1 (1) | 583 aa |
- Comparative Orthology
- Alliance
- Rahmati, M., Chebli, J., Banote, R.K., Roselli, S., Agholme, L., Zetterberg, H., Abramsson, A. (2024) Fine-tuning amyloid precursor protein expression through non-sense mediated mRNA decay. eNeuro. 11(6):
- Valcarce, D.G., Riesco, M.F., Cuesta-Martín, L., Esteve-Codina, A., Martínez-Vázquez, J.M., Robles, V. (2023) Stress decreases spermatozoa quality and induces molecular alterations in zebrafish progeny. BMC Biology. 21:7070
- Ma, Z., Zhu, P., Shi, H., Guo, L., Zhang, Q., Chen, Y., Chen, S., Zhang, Z., Peng, J., Chen, J. (2019) PTC-bearing mRNA elicits a genetic compensation response via Upf3a and COMPASS components. Nature. 568(7751):259-263
- Quiniou, S.M., Wilson, M., and Boudinot, P. (2011) Processing of fish Ig heavy chain transcripts: Diverse splicing patterns and unusual nonsense mediated decay. Developmental and comparative immunology. 35(9):949-58
- Wittkopp, N., Huntzinger, E., Weiler, C., Saulière, J., Schmidt, S., Sonawane, M., and Izaurralde, E. (2009) Nonsense-mediated mRNA decay effectors are essential for zebrafish embryonic development and survival. Molecular and cellular biology. 29(13):3517-3528
- Geisler, R., Rauch, G.J., Baier, H., van Bebber, F., Brobeta, L., Dekens, M.P., Finger, K., Fricke, C., Gates, M.A., Geiger, H., Geiger-Rudolph, S., Gilmour, D., Glaser, S., Gnugge, L., Habeck, H., Hingst, K., Holley, S., Keenan, J., Kirn, A., Knaut, H., Lashkari, D., Maderspacher, F., Martyn, U., Neuhauss, S., Neumann, C., Nicolson, T., Pelegri, F., Ray, R., Rick, J.M., Roehl, H., Roeser, T., Schauerte, H.E., Schier, A.F., Schönberger, U., Schönthaler, H.-B., Schulte-Merker, S., Seydler, C., Talbot, W.S., Weiler, C., Nüsslein-Volhard, C., and Haffter, P. (1999) A radiation hybrid map of the zebrafish genome. Nature Genetics. 23(1):86-89
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