Gene
lrrc32
- ID
- ZDB-GENE-090630-1
- Name
- leucine rich repeat containing 32
- Symbol
- lrrc32 Nomenclature History
- Previous Names
-
- si:ch73-211p17.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Acts upstream of or within platelet activation. Predicted to be located in membrane. Orthologous to human LRRC32 (leucine rich repeat containing 32).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Lin et al., 2017
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from O'Connor et al., 2009
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| MO1-lrrc32 | N/A | O'Connor et al., 2009 |
| MO2-lrrc32 | N/A | O'Connor et al., 2009 |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cleft palate, proliferative retinopathy, and developmental delay | 619074 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Leucine-rich repeat | Leucine-rich repeat domain superfamily | Leucine-rich repeat, typical subtype | Multifunctional Developmental and Immune Receptor |
|---|---|---|---|---|---|---|
| UniProtKB:E7FFN8 | InterPro | 659 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
lrrc32-201
(1)
|
Ensembl | 1,980 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-211P17 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001920541 (1) | |||
| Genomic | GenBank:CU469093 (1) | 94858 nt | ||
| Polypeptide | UniProtKB:E7FFN8 (1) | 659 aa |
- Lin, Q., Zhang, Y., Zhou, R., Zheng, Y., Zhao, L., Huang, M., Zhang, X., Leung, A.Y., Zhang, W., Zhang, Y. (2017) Establishment of a congenital amegakaryocytic thrombocytopenia model and a thrombocyte-specific reporter line in zebrafish. Leukemia. 31(5):1206-1216
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- O'Connor, M.N., Salles, I.I., Cvejic, A., Watkins, N.A., Walker, A., Garner, S.F., Jones, C.I., Macaulay, I.C., Steward, M., Zwaginga, J.J., Bray, S.L., Dudbridge, F., de Bono, B., Goodall, A.H., Deckmyn, H., Stemple, D.L., and Ouwehand, W.H. (2009) Functional genomics in zebrafish permits rapid characterization of novel platelet membrane proteins. Blood. 113(19):4754-4762
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