Gene
cnga3a
- ID
- ZDB-GENE-090611-2
- Name
- cyclic nucleotide gated channel subunit alpha 3a
- Symbol
- cnga3a Nomenclature History
- Previous Names
-
- cnga3
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable cGMP binding activity; intracellularly cAMP-activated cation channel activity; and intracellularly cGMP-activated cation channel activity. Predicted to be involved in monoatomic cation transmembrane transport. Predicted to act upstream of or within monoatomic ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of intracellular cyclic nucleotide activated cation channel complex. Predicted to be active in plasma membrane. Is expressed in brain; gonad; heart; and sensory system. Human ortholog(s) of this gene implicated in achromatopsia 2 and color blindness. Orthologous to human CNGA3 (cyclic nucleotide gated channel subunit alpha 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| achromatopsia 2 | Alliance | Achromatopsia 2 | 216900 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018488 | Cyclic nucleotide-binding, conserved site |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR005821 | Ion transport domain |
| Domain | IPR032406 | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain |
| Family | IPR050866 | Cyclic nucleotide-gated cation channel |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding, conserved site | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Cyclic nucleotide-gated cation channel | Cyclic nucleotide-gated channel, C-terminal leucine zipper domain | Ion transport domain | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PN18 | InterPro | 706 | |||||||
| UniProtKB:A0A8M3ATJ7 | InterPro | 664 | |||||||
| UniProtKB:A0A8M2BDH8 | InterPro | 765 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cnga3a-201
(1)
|
Ensembl | 2,136 nt | ||
| mRNA |
cnga3a-202
(1)
|
Ensembl | 2,807 nt | ||
| mRNA |
cnga3a-203
(1)
|
Ensembl | 2,115 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-22G9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005166084 (1) | 5851 nt | ||
| Genomic | GenBank:CR388007 (1) | 128128 nt | ||
| Polypeptide | UniProtKB:A0A8M2BDH8 (1) | 765 aa |
| Species | Symbol | Chromosome | Accession # | Evidence |
|---|---|---|---|---|
| Human | CNGA3 | 2 | Amino acid sequence comparison (1) |
- Wang, Y.Y., Liang, X.F., Lu, K. (2023) Knockout of SWS2 in zebrafish (Danio rerio) reveals its roles in feeding and phototactic behaviors. Gene. 897:148059
- Rozenblat, R., Tovin, A., Zada, D., Lebenthal-Loinger, I., Lerer-Goldshtein, T., Appelbaum, L. (2022) Genetic and Neurological Deficiencies in the Visual System of mct8 Mutant Zebrafish. International Journal of Molecular Sciences. 23(5):
- Tang, S.L., Liang, X.F., He, S., Li, L., Alam, M.S., Wu, J. (2022) Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Frontiers in genetics. 13:909091
- He, L., Chen, Y., Hu, Z., Zhang, Y., Wang, Y., Wei, J., Fan, Z., Xu, J., Peng, M., Zhao, K., Zhang, H., Liu, C. (2021) Evaluation of 3,4,4,9-trichlorocarbanilide to zebrafish developmental toxicity based on transcriptomics analysis. Chemosphere. 278:130349
- Blechman, J., Anbalagan, S., Matthews, G.G., Levkowitz, G. (2018) Genome Editing Reveals Idiosyncrasy of CNGA2 Ion Channel-Directed Antibody Immunoreactivity Toward Oxytocin. Frontiers in cell and developmental biology. 6:117
- Matern, M.S., Beirl, A., Ogawa, Y., Song, Y., Paladugu, N., Kindt, K.S., Hertzano, R. (2018) Transcriptomic Profiling of Zebrafish Hair Cells Using RiboTag. Frontiers in cell and developmental biology. 6:47
- Shim, H., Kim, J.H., Kim, C.Y., Hwang, S., Kim, H., Yang, S., Lee, J.E., Lee, I. (2016) Function-driven discovery of disease genes in zebrafish using an integrated genomics big data resource. Nucleic acids research. 44:9611-9623
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Laranjeiro, R., Whitmore, D. (2014) Transcription factors involved in retinogenesis are co-opted by the circadian clock following photoreceptor differentiation. Development (Cambridge, England). 141(13):2644-56
- Sato, Y., Hashiguchi, Y., and Nishida, M. (2009) Temporal pattern of loss/persistence of duplicate genes involved in signal transduction and metabolic pathways after teleost-specific genome duplication. BMC Evolutionary Biology. 9:127
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