Gene
syt7b
- ID
- ZDB-GENE-090601-6
- Name
- synaptotagmin VIIb
- Symbol
- syt7b Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 7 Mapping Details/Browsers
- Description
- Predicted to enable SNARE binding activity; calcium ion sensor activity; and calcium-dependent phospholipid binding activity. Acts upstream of or within asynchronous neurotransmitter secretion. Predicted to be located in membrane. Predicted to be active in axon; plasma membrane; and synaptic vesicle. Is expressed in brain; eye; female organism; and motor neurons. Orthologous to human SYT7 (synaptotagmin 7).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Wen et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la025792Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la025793Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| la029277Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa9201 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | C2 domain | C2 domain superfamily | Synaptotagmin | Synaptotagmin 7, C2A domain | Synaptotagmin 7, C2B domain |
|---|---|---|---|---|---|---|---|
| UniProtKB:D4P8S0 | InterPro | 488 | |||||
| UniProtKB:A0A8M9PNI7 | InterPro | 380 | |||||
| UniProtKB:A0AB32TTK3 | InterPro | 654 | |||||
| UniProtKB:A0AB32TXZ0 | InterPro | 605 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-311B20 | ||
| Contained in | BAC | CH73-370C23 | ||
| Contained in | BAC | CH211-261J13 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001245957 (1) | 1467 nt | ||
| Genomic | GenBank:AL953869 (2) | 171417 nt | ||
| Polypeptide | UniProtKB:A0AB32TTK3 (1) | 654 aa |
- Shiao, M.S., Liu, S.T., Siriwatcharapibool, G., Thongpradit, S., Khunpanich, P., Tong, S.K., Huang, C.H., Jinawath, N., Chou, M.Y. (2024) Conserved expression of the zebrafish syt4 gene in GABAergic neurons in the cerebellum of adult fishes revealed by mammalian SYT4 immunoreactive-like signals. Heliyon. 10:e30575e30575
- Henry, D., Joselevitch, C., Matthews, G.G., Wollmuth, L.P. (2021) Expression and distribution of synaptotagmin family members in the zebrafish retina. The Journal of comparative neurology. 530(4):705-728
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Liu, C., Hu, J., Qu, C., Wang, L., Huang, G., Niu, P., Zhong, Z., Hong, F., Wang, G., Postlethwait, J.H., Wang, H. (2015) Molecular evolution and functional divergence of zebrafish (Danio rerio) cryptochrome genes. Scientific Reports. 5:8113
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Craxton, M. (2010) A manual collection of Syt, Esyt, Rph3a, Rph3al, Doc2, and Dblc2 genes from 46 metazoan genomes - an open access resource for neuroscience and evolutionary biology. BMC Genomics. 11:37
- Wen, H., Linhoff, M.W., McGinley, M.J., Li, G.L., Corson, G.M., Mandel, G., and Brehm, P. (2010) Distinct roles for two synaptotagmin isoforms in synchronous and asynchronous transmitter release at zebrafish neuromuscular junction. Proceedings of the National Academy of Sciences of the United States of America. 107(31):13906-13911
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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