Gene
itln3
- ID
- ZDB-GENE-090527-4
- Name
- intelectin 3
- Symbol
- itln3 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable oligosaccharide binding activity. Predicted to be active in extracellular space. Is expressed in brain; digestive system; heart; and pleuroperitoneal region. Orthologous to human ITLN1 (intelectin 1) and ITLN2 (intelectin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7386 | Allele with one point mutation | Unknown | Missense | ENU | |
| sa28277 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa35654 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| tpu1 | Allele with one deletion | Exon 2 | Frameshift, Premature Stop | CRISPR | |
| tpu2 | Allele with one delins | Exon 2 | Frameshift, Premature Stop | CRISPR |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Fibrinogen, alpha/beta/gamma chain, C-terminal globular domain | Fibrinogen, alpha/beta/gamma chain, C-terminal globular, subdomain 1 | Fibrinogen-like, C-terminal |
|---|---|---|---|---|---|
| UniProtKB:C1IHU9 | InterPro | 314 | |||
| UniProtKB:A0A8M1NUF6 | InterPro | 314 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-121B13 | ||
| Contained in | BAC | DKEY-33H4 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001159584 (1) | 1175 nt | ||
| Genomic | GenBank:CT990569 | 303266 nt | ||
| Polypeptide | UniProtKB:A0A8M1NUF6 (1) | 314 aa |
No data available
- Ojanen, M.J.T., Uusi-Mäkelä, M.I.E., Harjula, S.E., Saralahti, A.K., Oksanen, K.E., Kähkönen, N., Määttä, J.A.E., Hytönen, V.P., Pesu, M., Rämet, M. (2019) Intelectin 3 is dispensable for resistance against a mycobacterial infection in zebrafish (Danio rerio). Scientific Reports. 9:995
- Yan, J., Chen, L., Liu, Z., Chen, Y., Sun, Y., Han, J., Feng, L. (2018) The D5 region of the intelectin domain is a new type of carbohydrate recognition domain in the intelectin gene family. Developmental and comparative immunology. 85:150-160
- Takada, N., Omae, M., Sagawa, F., Chi, N.C., Endo, S., Kozawa, S., Sato, T.N. (2017) Re-evaluating functional landscape of the cardiovascular system during development. Biology Open. 6(11):1756-1770
- Chen, L., Yan, J., Sun, W., Sui, C., Qi, J., Du, Y., Feng, L. (2016) A zebrafish intelectin ortholog agglutinates both Gram-negative and Gram-positive bacteria with binding capacity to bacterial polysaccharide. Fish & shellfish immunology. 55:729-36
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Benard, E.L., Roobol, S.J., Spaink, H.P., Meijer, A.H. (2014) Phagocytosis of mycobacteria by zebrafish macrophages is dependent on the scavenger receptor Marco, a key control factor of pro-inflammatory signalling. Developmental and comparative immunology. 47(2):223-33
- Podok, P., Xu, L., Xu, D., Lu, L. (2014) Different expression profiles of Interleukin 11 (IL-11), Intelectin (ITLN) and Purine nucleoside phosphorylase 5a (PNP 5a) in crucian carp (Carassius auratus gibelio) in response to Cyprinid herpesvirus 2 and Aeromonas hydrophila. Fish & shellfish immunology. 38:65-73
- Veneman, W.J., Stockhammer, O.W., de Boer, L., Zaat, S.A., Meijer, A.H., and Spaink, H.P. (2013) A zebrafish high throughput screening system used for Staphylococcus epidermidis infection marker discovery. BMC Genomics. 14(1):255
- Zheng, W., Xu, H., Lam, S.H., Luo, H., Karuturi, R.K., and Gong, Z. (2013) Transcriptomic analyses of sexual dimorphism of the zebrafish liver and the effect of sex hormones. PLoS One. 8(1):e53562
- Yang, D., Liu, Q., Yang, M., Wu, H., Wang, Q., Xiao, J., and Zhang, Y. (2012) RNA-seq liver transcriptome analysis reveals an activated MHC-I pathway and an inhibited MHC-II pathway at the early stage of vaccine immunization in zebrafish. BMC Genomics. 13(1):319
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