Gene
dgke
- ID
- ZDB-GENE-090512-7
- Name
- diacylglycerol kinase, epsilon
- Symbol
- dgke Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to enable ATP-dependent diacylglycerol kinase activity. Predicted to be involved in glycerolipid metabolic process and intracellular signal transduction. Predicted to act upstream of or within lipid metabolic process; phosphorylation; and signal transduction. Predicted to be active in membrane. Human ortholog(s) of this gene implicated in nephrotic syndrome type 7. Orthologous to human DGKE (diacylglycerol kinase epsilon).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa20679 | Allele with one point mutation | Unknown | Splice Site | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| nephrotic syndrome type 7 | Alliance | Nephrotic syndrome, type 7 | 615008 |
| nephrotic syndrome type 7 | Alliance | {Hemolytic uremic syndrome, atypical, susceptibility to, 7} | 615008 |
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Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000756 | Diacylglycerol kinase, accessory domain |
| Domain | IPR001206 | Diacylglycerol kinase, catalytic domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Family | IPR037607 | Diacylglycerol kinase |
| Homologous_superfamily | IPR016064 | NAD kinase/diacylglycerol kinase-like domain superfamily |
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Domain Details Per Protein
| Protein | Additional Resources | Length | C1-like domain superfamily | Diacylglycerol kinase | Diacylglycerol kinase, accessory domain | Diacylglycerol kinase, catalytic domain | Inorganic polyphosphate/ATP-NAD kinase, N-terminal | NAD kinase/diacylglycerol kinase-like domain superfamily | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NVX4 | InterPro | 564 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-31G6 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001172228 (1) | 1695 nt | ||
| Genomic | GenBank:BX571728 (1) | 229059 nt | ||
| Polypeptide | UniProtKB:A0A8M1NVX4 (1) | 564 aa |