Gene

gnas

ID
ZDB-GENE-090417-2
Name
GNAS complex locus
Symbol
gnas Nomenclature History
Previous Names
  • Galpha s (1)
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have G-protein beta/gamma-subunit complex binding activity; GTPase activity; and signaling receptor binding activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to localize to heterotrimeric G-protein complex. Is expressed in brain; gill; head; heart; and olfactory epithelium. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; pituitary adenoma 3; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
3 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With gnas Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
ACTH-independent macronodular adrenal hyperplasia 1 Alliance ACTH-independent macronodular adrenal hyperplasia 219080
Albright's hereditary osteodystrophy Alliance Pseudohypoparathyroidism Ia 103580
McCune Albright syndrome Alliance McCune-Albright syndrome, somatic, mosaic 174800
pituitary adenoma 3 Alliance Pituitary adenoma 3, multiple types, somatic 617686
progressive osseous heteroplasia Alliance Osseous heteroplasia, progressive 166350
pseudohypoparathyroidism Alliance Pseudohypoparathyroidism Ic 612462
pseudohypoparathyroidism type IB Alliance Pseudohypoparathyroidism Ib 603233
pseudopseudohypoparathyroidism Alliance Pseudopseudohypoparathyroidism 612463
Associated With gnas Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR000367 G-protein alpha subunit, group S
Family IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
Homologous_superfamily IPR011025 G protein alpha subunit, helical insertion
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length G-protein alpha subunit, group S G protein alpha subunit, helical insertion Guanine nucleotide binding protein (G-protein), alpha subunit P-loop containing nucleoside triphosphate hydrolase
UniProtKB:F1QJX7 379
UniProtKB:F8W2Q1 114
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations