Gene
gnas
- ID
- ZDB-GENE-090417-2
- Name
- GNAS complex locus
- Symbol
- gnas Nomenclature History
- Previous Names
-
- Galpha s (1)
- Type
- protein_coding_gene
- Location
- Chr: 6 Mapping Details/Browsers
- Description
- Predicted to have G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to localize to heterotrimeric G-protein complex. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; obesity; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Is expressed in brain; gill; head; heart; and olfactory epithelium. Orthologous to human GNAS (GNAS complex locus).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| ACTH-independent macronodular adrenal hyperplasia 1 | Alliance | ACTH-independent macronodular adrenal hyperplasia 1, somatic | 219080 |
| McCune Albright syndrome | Alliance | McCune-Albright syndrome, somatic mosaic | 174800 |
| pituitary adenoma 3 | Alliance | Pituitary adenoma 3, multiple types, somatic | 617686 |
| progressive osseous heteroplasia | Alliance | Osseous heteroplasia, progressive | 166350 |
| pseudohypoparathyroidism type 1A | Alliance | Pseudohypoparathyroidism Ia | 103580 |
| pseudohypoparathyroidism type 1B | Alliance | Pseudohypoparathyroidism Ib | 603233 |
| pseudohypoparathyroidism type 1C | Alliance | Pseudohypoparathyroidism Ic | 612462 |
| pseudopseudohypoparathyroidism | Alliance | Pseudopseudohypoparathyroidism | 612463 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR000367 | G-protein alpha subunit, group S |
| Family | IPR001019 | Guanine nucleotide binding protein (G-protein), alpha subunit |
| Homologous_superfamily | IPR011025 | G protein alpha subunit, helical insertion |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
Domain Details Per Protein
| Protein | Length | G-protein alpha subunit, group S | G protein alpha subunit, helical insertion | Guanine nucleotide binding protein (G-protein), alpha subunit | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PZ01
|
419 | ||||
|
UniProtKB:F1QJX7
|
379 |
Interactions and Pathways
No data available
Plasmids
No data available