ZFIN is now using GRCz12tu for Genomic Data
Gene
kcnh5b
- ID
- ZDB-GENE-090319-1
- Name
- potassium voltage-gated channel, subfamily H (eag-related), member 5b
- Symbol
- kcnh5b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport and regulation of membrane potential. Predicted to be located in membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human KCNH5 (potassium voltage-gated channel subfamily H member 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Developmental and epileptic encephalopathy 112 | 620537 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000014 | PAS domain |
| Domain | IPR000595 | Cyclic nucleotide-binding domain |
| Domain | IPR000700 | PAS-associated, C-terminal |
| Domain | IPR005821 | Ion transport domain |
| Family | IPR003938 | Potassium channel, voltage-dependent, EAG/ELK/ERG-like |
| Family | IPR003949 | Potassium channel, voltage-dependent, EAG |
| Family | IPR050818 | Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type |
| Homologous_superfamily | IPR014710 | RmlC-like jelly roll fold |
| Homologous_superfamily | IPR018490 | Cyclic nucleotide-binding domain superfamily |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Repeat | IPR001610 | PAC motif |
Domain Details Per Protein
| Protein | Additional Resources | Length | Cyclic nucleotide-binding domain | Cyclic nucleotide-binding domain superfamily | Ion transport domain | PAC motif | PAS-associated, C-terminal | PAS domain | PAS domain superfamily | Potassium channel, voltage-dependent, EAG | Potassium channel, voltage-dependent, EAG/ELK/ERG-like | Potassium channel, voltage-dependent, EAG/ELK/ERG-like, animal-type | RmlC-like jelly roll fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1RRD3 | InterPro | 1005 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
kcnh5b-201
(1)
|
Ensembl | 2,889 nt | ||
| mRNA |
kcnh5b-202
(1)
|
Ensembl | 2,025 nt | ||
| mRNA |
kcnh5b-203
(1)
|
Ensembl | 2,934 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers
- Comparative Orthology
- Alliance