Gene

ddr2a

ID
ZDB-GENE-090316-2
Name
discoidin domain receptor tyrosine kinase 2a
Symbol
ddr2a Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 6 Mapping Details/Browsers
Description
Predicted to have collagen binding activity and protein tyrosine kinase collagen receptor activity. Predicted to be involved in multicellular organism development; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to integral component of plasma membrane and receptor complex. Orthologous to human DDR2 (discoidin domain receptor tyrosine kinase 2).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ddr2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
spondylometaepiphyseal dysplasia, short limb-hand type Alliance Spondylometaepiphyseal dysplasia, short limb-hand type 271665
Warburg-Cinotti syndrome 618175
Associated With ddr2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Conserved_site IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
Domain IPR000421 Coagulation factor 5/8 C-terminal domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Family IPR034299 Discoidin domain-containing receptor 1/2
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Coagulation factor 5/8 C-terminal domain Discoidin domain-containing receptor 1/2 Galactose-binding-like domain superfamily Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, receptor class II, conserved site
UniProtKB:E7FFT8 868
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations