Gene
arhgef38
- ID
- ZDB-GENE-090313-83
- Name
- Rho guanine nucleotide exchange factor (GEF) 38
- Symbol
- arhgef38 Nomenclature History
- Previous Names
-
- si:ch211-216c6.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in Golgi stack and anchoring junction. Orthologous to human ARHGEF38 (Rho guanine nucleotide exchange factor 38).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Lansdon et al., 2022
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | AH/BAR domain superfamily | BAR domain | Dbl homology (DH) domain superfamily | Dbl homology domain | Dynamin-binding and Rho GEF | Guanine-nucleotide dissociation stimulator, CDC24, conserved site | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3ASM7 | InterPro | 762 | ||||||||
| UniProtKB:A0A8M3AIF8 | InterPro | 548 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arhgef38-201
(1)
|
Ensembl | 2,764 nt |
1 - 1 of 1
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance
- Lansdon, L.A., Dickinson, A., Arlis, S., Liu, H., Hlas, A., Hahn, A., Bonde, G., Long, A., Standley, J., Tyryshkina, A., Wehby, G., Lee, N.R., Daack-Hirsch, S., Mohlke, K., Girirajan, S., Darbro, B.W., Cornell, R.A., Houston, D.W., Murray, J.C., Manak, J.R. (2022) Genome-wide analysis of copy number variation in humans with cleft lip and/or cleft palate identifies COBLL1, RIC1, and ARHGEF38 as clefting genes. American journal of human genetics. 110(1):71-91
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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