Gene
cdc25d
- ID
- ZDB-GENE-090313-74
- Name
- cell division cycle 25 homolog d
- Symbol
- cdc25d Nomenclature History
- Previous Names
-
- si:ch211-202h22.3
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables phosphoprotein phosphatase activity. Acts upstream of or within regulation of G2/M transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Is expressed in olfactory placode and somite.
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Nogare et al., 2007
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Verduzco et al., 2012
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa30807 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa31237 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39706 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa39707 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| zko1098a | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-cdc25d | China Zebrafish Resource Center (CZRC) | |
| MO1-cdc25d | N/A | Verduzco et al., 2012 |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | M-phase inducer phosphatase | Rhodanese-like domain | Rhodanese-like domain superfamily |
|---|---|---|---|---|---|
| UniProtKB:A0A8M6Z595 | InterPro | 388 | |||
| UniProtKB:B5LY74 | InterPro | 387 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
cdc25d-201
(1)
|
Ensembl | 1,528 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-202H22 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001134682 (1) | 1499 nt | ||
| Genomic | GenBank:BX119918 (1) | 141342 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z595 (1) | 388 aa |
No data available
- Liu, Y., Sepich, D.S., Solnica-Krezel, L. (2017) Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genetics. 13:e1006564
- Verduzco, D., Shepard Dovey, J., Shukla, A., Kodym, E., Skaug, B.A., and Amatruda, J.F. (2012) Multiple isoforms of CDC25 oppose ATM activity to maintain cell proliferation during vertebrate development. Molecular cancer research : MCR. 10(11):1451-1461
- Dalle Nogare, D.E., Pauerstein, P.T., and Lane, M.E. (2009) G2 acquisition by transcription-independent mechanism at the zebrafish midblastula transition. Developmental Biology. 326(1):131-142
- Nogare, D.E., Arguello, A., Sazer, S., and Lane, M.E. (2007) Zebrafish cdc25a is expressed during early development and limiting for post-blastoderm cell cycle progression. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(12):3427-3435
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