Gene
map3k1
- ID
- ZDB-GENE-090313-412
- Name
- mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
- Symbol
- map3k1 Nomenclature History
- Previous Names
-
- si:rp71-80a19.2
- Type
- protein_coding_gene
- Location
- Chr: 10 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6; breast cancer; gastrointestinal system cancer (multiple); and lung non-small cell carcinoma. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
---|---|---|---|
46,XY sex reversal 6 | Alliance | 46XY sex reversal 6 | 613762 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001841 | Zinc finger, RING-type |
Domain | IPR007527 | Zinc finger, SWIM-type |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR011989 | Armadillo-like helical |
Homologous_superfamily | IPR013083 | Zinc finger, RING/FYVE/PHD-type |
Homologous_superfamily | IPR016024 | Armadillo-type fold |
Domain Details Per Protein
Protein | Additional Resources | Length | Armadillo-like helical | Armadillo-type fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site | Zinc finger, RING/FYVE/PHD-type | Zinc finger, RING-type | Zinc finger, SWIM-type |
---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A8M2B1Q9 | InterPro | 1479 | |||||||||
UniProtKB:A0AB32TYS0 | InterPro | 1334 |
Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
---|---|---|---|---|---|
mRNA |
map3k1-201
(1)
|
Ensembl | 3,885 nt | ||
mRNA |
map3k1-202
(1)
|
Ensembl | 4,122 nt | ||
mRNA |
map3k1-203
(1)
|
Ensembl | 3,909 nt |
Interactions and Pathways
No data available
Plasmids
No data available