Gene

map3k1

ID
ZDB-GENE-090313-412
Name
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Symbol
map3k1 Nomenclature History
Previous Names
  • si:rp71-80a19.2
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have ATP binding activity; protein kinase activity; and zinc ion binding activity. Predicted to be involved in protein phosphorylation. Human ortholog(s) of this gene implicated in 46,XY sex reversal 6 and breast cancer. Orthologous to human MAP3K1 (mitogen-activated protein kinase kinase kinase 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With map3k1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
46,XY sex reversal 6 Alliance 46XY sex reversal 6 613762
Associated With map3k1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001841 Zinc finger, RING-type
Domain IPR007527 Zinc finger, SWIM-type
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR016024 Armadillo-type fold
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type Zinc finger, SWIM-type
UniProtKB:A0A0R4IZ86 1294
UniProtKB:A0A2R8QB94 1302
UniProtKB:A0A0R4IQU7 1334
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations