Gene
hpse2
- ID
- ZDB-GENE-090313-378
- Name
- heparanase 2
- Symbol
- hpse2 Nomenclature History
- Previous Names
-
- si:dkeyp-22h2.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable hydrolase activity, acting on glycosyl bonds. Predicted to be involved in extracellular matrix organization. Predicted to be located in membrane. Predicted to be active in extracellular matrix and extracellular space. Is expressed in liver. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human HPSE2 (heparanase 2 (inactive)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la018623Tg | Transgenic insertion | Unknown | Unknown | DNA |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| urofacial syndrome | Alliance | Urofacial syndrome 1 | 236730 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycoside hydrolase, family 79 | Glycoside hydrolase superfamily |
|---|---|---|---|---|
| UniProtKB:A0A8M3B5H5 | InterPro | 577 | ||
| UniProtKB:A0A8M3BEU7 | InterPro | 321 | ||
| UniProtKB:A0A8M3AZF6 | InterPro | 323 |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-227C19 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-22H2 | ZFIN Curated Data | |
| Contained in | BAC | DKEYP-34H12 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009307537 (1) | |||
| Genomic | GenBank:BX005330 (1) | 176880 nt | ||
| Polypeptide | UniProtKB:A0A8M3B5H5 (1) | 577 aa |
- Wang, X., Li, X., Wang, Y., Ren, Z., Du, X., Gao, J., Ji, G., Liu, Z. (2024) Nkx1.2 deletion decreases fat production in zebrafish. Obesity (Silver Spring, Md.). 32(7):1315-1328
- Boskovic, S., Marín-Juez, R., Jasnic, J., Reischauer, S., El Sammak, H., Kojic, A., Faulkner, G., Radojkovic, D., Stainier, D.Y.R., Kojic, S. (2018) Characterization of zebrafish (Danio rerio) muscle ankyrin repeat proteins reveals their conserved response to endurance exercise. PLoS One. 13:e0204312
- Lin, J.N., Chang, L.L., Lai, C.H., Lin, K.J., Lin, M.F., Yang, C.H., Lin, H.H., Chen, Y.H. (2015) Development of an Animal Model for Alcoholic Liver Disease in Zebrafish. Zebrafish. 12(4):271-80
- Petit, D., Teppa, E., Mir, A., Vicogne, D., Thisse, C., Thisse, B., Filloux, C., Harduin-Lepers, A. (2015) Integrative view of α2,3-sialyltransferases (ST3Gal) molecular and functional evolution in deuterostomes: significance of lineage specific losses. Mol. Biol. Evol.. 32(4):906-27
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Zhao, Y., Qin, W., Zhang, J.P., Hu, Z.Y., Tong, J.W., Ding, C.B., Peng, Z.G., Zhao, L.X., Song, D.Q., and Jiang, J.D. (2013) HCV IRES-Mediated Core Expression in Zebrafish. PLoS One. 8(3):e56985
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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