Gene
ccm2l
- ID
- ZDB-GENE-090313-248
- Name
- CCM2 like scaffold protein
- Symbol
- ccm2l Nomenclature History
- Previous Names
-
- ccml2
- si:dkey-223d9.2
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Acts upstream of or within anterior/posterior axis specification; heart contraction; and heart morphogenesis. Is expressed in heart and notochord. Orthologous to human CCM2L (CCM2 like scaffold protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Rosen et al., 2013
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Targeting Reagent | Created Alleles | Citations |
---|---|---|
MO1-ccm2l | N/A | Rosen et al., 2013 |
MO2-ccm2l | N/A | Rosen et al., 2013 |
MO3-ccm2l | N/A | Cullere et al., 2015 |
MO4-ccm2l | N/A | Cullere et al., 2015 |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-223D9 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
Genomic | GenBank:CR847525 | 268665 nt |
- Hu, M., Liu, P., Lu, S., Wang, Z., Lyu, Z., Liu, H., Sun, Y., Liu, F., Tian, J. (2021) Myocardial protective effect and transcriptome profiling of Naoxintong on cardiomyopathy in zebrafish. Chinese Medicine. 16:119
- Chestnut, B., Sumanas, S. (2019) Zebrafish etv2 knock-in line labels vascular endothelial and blood progenitor cells. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(2):245-261
- Cullere, X., Plovie, E., Bennett, P.M., MacRae, C.A., Mayadas, T.N. (2015) The cerebral cavernous malformation proteins CCM2L and CCM2 prevent the activation of the MAP kinase MEKK3. Proceedings of the National Academy of Sciences of the United States of America. 112(46):14284-9
- Rosen, J.N., Sogah, V.M., Ye, L.Y., and Mably, J.D. (2013) Ccm2-like is required for cardiovascular development as a novel component of the Heg-CCM pathway. Developmental Biology. 376(1):74-85
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