ZFIN is now using GRCz12tu for Genomic Data
Gene
tet2
- ID
- ZDB-GENE-090312-98
- Name
- tet methylcytosine dioxygenase 2
- Symbol
- tet2 Nomenclature History
- Previous Names
-
- tet2l (1)
- im:7136741
- si:ch211-216c6.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA 5-methylcytosine dioxygenase activity. Predicted to be involved in myeloid cell differentiation and positive regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136741 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
| Immunodeficiency 75 | 619126 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | tet2zdf20/zdf20 | standard conditions | Gjini et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 2OGFeDO JBP1/TET, oxygenase domain | Methylcytosine dioxygenase TET1/2/3 | Methylcytosine dioxygenase TET1-3, oxygenase domain |
|---|---|---|---|---|---|
| UniProtKB:E7F958 | InterPro | 1715 | |||
| UniProtKB:A0AA52Z4K0 | InterPro | 1715 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers