Gene
tet2
- ID
- ZDB-GENE-090312-98
- Name
- tet methylcytosine dioxygenase 2
- Symbol
- tet2 Nomenclature History
- Previous Names
-
- tet2l (1)
- im:7136741
- si:ch211-216c6.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Enables 5-methylcytosine dioxygenase activity and broad specificity oxidative DNA demethylase activity. Involved in regulation of gene expression. Acts upstream of or within cell surface receptor signaling pathway; endothelial to hematopoietic transition; and hemopoiesis. Predicted to be located in chromosome. Predicted to be active in nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136741 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| au59 | Allele with one deletion | Exon 1 | Frameshift, Premature Stop | TALEN | |
| hsi12 | Allele with one deletion | Exon 2 | Unknown | CRISPR | |
| ihb2019 | Allele with one insertion | Exon 2 | Unknown | TALEN | |
| ki117 | Allele with one deletion | Unknown | Unknown | not specified | |
| mk17 | Allele with one deletion | Exon 8 | Frameshift, Premature Stop | TALEN | |
| sa8671 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11184 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa13278 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa14623 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa32686 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
| Immunodeficiency 75 | 619126 |
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| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | tet2zdf20/zdf20 | standard conditions | Gjini et al., 2015 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 2OGFeDO JBP1/TET, oxygenase domain | Methylcytosine dioxygenase TET1/2/3 | Methylcytosine dioxygenase TET1-3, oxygenase domain |
|---|---|---|---|---|---|
| UniProtKB:E7F958 | InterPro | 1715 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-216C6 | ZFIN Curated Data | |
| Encodes | EST | IMAGE:7136741 | Thisse et al., 2004 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_005159903 (1) | 6501 nt | ||
| Genomic | GenBank:CU570873 (1) | 197580 nt | ||
| Polypeptide | UniProtKB:E7F958 (1) | 1715 aa |
- Lawir, D.F., Soza-Ried, C., Iwanami, N., Siamishi, I., Bylund, G.O., O Meara, C., Sikora, K., Kanzler, B., Johansson, E., Schorpp, M., Cauchy, P., Boehm, T. (2024) Antagonistic interactions safeguard mitotic propagation of genetic and epigenetic information in zebrafish. Communications biology. 7:3131
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Liang, F., Dong, Z., Ye, J., Hu, W., Bhandari, R.K., Mai, K., Wang, X. (2023) In vivo DNA methylation editing in zebrafish. Epigenetics. 18:21923262192326
- Neelamraju, Y., Gjini, E., Chhangawala, S., Fan, H., He, S., Jing, C.B., Nguyen, A.T., Prajapati, S., Sheridan, C., Houvras, Y., Melnick, A., Look, A.T., Garrett-Bakelman, F.E. (2023) Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome. Frontiers in hematology. 2:
- Yang, R., Zhang, Y., Deng, Y., Yang, Y., Zhong, W., Zhu, L. (2023) 2-Ethylhexyl Diphenyl Phosphate Causes Obesity in Zebrafish by Stimulating Overeating via Inhibition of Dopamine Receptor D2. Environmental science & technology. 57(38):14162-14172
- Avagyan, S., Henninger, J.E., Mannherz, W.P., Mistry, M., Yoon, J., Yang, S., Weber, M.C., Moore, J.L., Zon, L.I. (2021) Resistance to inflammation underlies enhanced fitness in clonal hematopoiesis. Science (New York, N.Y.). 374:768-772
- Banks, K.M., Lan, Y., Evans, T. (2021) Tet Proteins Regulate Neutrophil Granulation in Zebrafish through Demethylation of socs3b mRNA. Cell Reports. 34:108632
- Guo, W., Lei, L., Shi, X., Li, R., Wang, Q., Han, J., Yang, L., Chen, L., Zhou, B. (2021) Nonalcoholic Fatty Liver Disease Development in Zebrafish upon Exposure to Bis(2-ethylhexyl)-2,3,4,5-tetrabromophthalate, a Novel Brominated Flame Retardant. Environmental science & technology. 55(10):6926-6935
- Rajan, V., Collett, K., Woodside, R., Prykhozhij, S.V., Moksa, M., Carles, A., Wong, M., Liebman, M., Hirst, M., Berman, J.N. (2021) Stress hematopoiesis induces a proliferative advantage in TET2 deficiency. Leukemia. 36(3):809-820
- Ross, S.E., Hesselson, D., Bogdanovic, O. (2021) Developmental Accumulation of Gene Body and Transposon Non-CpG Methylation in the Zebrafish Brain. Frontiers in cell and developmental biology. 9:643603
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