Gene
tet2
- ID
- ZDB-GENE-090312-98
- Name
- tet methylcytosine dioxygenase 2
- Symbol
- tet2 Nomenclature History
- Previous Names
-
- tet2l (1)
- im:7136741
- si:ch211-216c6.1
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Exhibits methylcytosine dioxygenase activity. Involved in several processes, including cell surface receptor signaling pathway; endothelial to hematopoietic transition; and primitive erythrocyte differentiation. Predicted to localize to nucleus. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 13 figures from 11 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- IMAGE:7136741 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- 13 figures from 3 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| myelodysplastic syndrome | Alliance | Myelodysplastic syndrome, somatic | 614286 |
| Immunodeficiency 75 | 619126 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| myelodysplastic syndrome | tet2zdf20/zdf20 | standard conditions | Gjini et al., 2015 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | 2OGFeDO JBP1/TET, oxygenase domain | Methylcytosine dioxygenase TET1/2/3 | Methylcytosine dioxygenase TET1-3, oxygenase domain |
|---|---|---|---|---|
|
UniProtKB:E7F958
|
1715 |
Interactions and Pathways
No data available
Plasmids
No data available