Gene

wnk3

ID

ZDB-GENE-090312-81

Name

WNK lysine deficient protein kinase 3

Symbol

wnk3 Nomenclature History

Previous Names

wnk3l (1)
im:7152756
si:dkey-151g10.3 (1)
wnk3-like (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Description

Predicted to have chloride channel inhibitor activity; potassium channel inhibitor activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; protein phosphorylation; and regulation of metal ion transport. Predicted to localize to cytosol.

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Thisse et al., 2004

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

IMAGE:7152756 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wnk3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Prieto syndrome	Alliance	Prieto syndrome	309610

Associated With wnk3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Domain	IPR000719	Protein kinase domain
Domain	IPR024678	Serine/threonine-protein kinase OSR1/WNK, CCT domain
Family	IPR050588	With No Lysine (K) Ser/Thr Protein Kinase
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site	Serine/threonine-protein kinase OSR1/WNK, CCT domain	With No Lysine (K) Ser/Thr Protein Kinase
UniProtKB:A0A8M9PFG8 InterPro	2994
UniProtKB:A0A8M3B680 InterPro	2693
UniProtKB:A0A8M9PTI7 InterPro	3056
UniProtKB:A0A8M3AVG7 InterPro	3053
UniProtKB:A0A8M9PWV5 InterPro	1953
UniProtKB:A0A8M9PL63 InterPro	2696
UniProtKB:A0A8N7TFG0 InterPro	3006
UniProtKB:A0A8M3ANR2 InterPro	1950
UniProtKB:A0A8M9P5H4 InterPro	3009
UniProtKB:A0A8M3AN04 InterPro	2991

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	si:dkey-151g10.3-201 (1) Ensembl	Ensembl	2,000 nt	Select Tool
mRNA	si:dkey-151g10.3-202 (1) Ensembl	Ensembl	399 nt	Select Tool
mRNA	si:dkey-151g10.3-203 (1) Ensembl	Ensembl	1,567 nt	Select Tool
mRNA	si:dkey-151g10.3-204 (1) Ensembl	Ensembl	1,869 nt	Select Tool ZFIN BLAST
mRNA	si:dkey-151g10.3-205 (1) Ensembl	Ensembl	1,338 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations