Gene
arfgef2
- ID
- ZDB-GENE-090312-50
- Name
- ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
- Symbol
- arfgef2 Nomenclature History
- Previous Names
-
- si:dkey-192i18.4
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Lu et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Lu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| periventricular nodular heterotopia | Alliance | Periventricular heterotopia with microcephaly | 608097 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000904 | Sec7 domain |
| Domain | IPR015403 | Mon2/Sec7/BIG1-like, HDS |
| Domain | IPR032629 | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain |
| Domain | IPR032691 | Mon2/Sec7/BIG1-like, HUS domain |
| Domain | IPR046455 | Sec7/BIG1-like, C-terminal domain |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
| Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
| Protein | Length | Armadillo-like helical | Armadillo-type fold | Mon2/Sec7/BIG1-like, dimerisation and cyclophilin-binding domain | Mon2/Sec7/BIG1-like, HDS | Mon2/Sec7/BIG1-like, HUS domain | Sec7/BIG1-like, C-terminal domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:E7FCG1
|
1846 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
arfgef2-201
(1)
|
Ensembl | 5,541 nt | ||
| mRNA |
arfgef2-202
(1)
|
Ensembl | 5,909 nt |
Interactions and Pathways
No data available
Plasmids
No data available