Gene

rapgef3

ID
ZDB-GENE-090312-38
Name
Rap guanine nucleotide exchange factor (GEF) 3
Symbol
rapgef3 Nomenclature History
Previous Names
  • si:dkey-27m20.2
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in plasma membrane. Is expressed in neuromast. Orthologous to human RAPGEF3 (Rap guanine nucleotide exchange factor 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rapgef3 Human Ortholog
No data available
Associated With rapgef3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019804 Ras guanine-nucleotide exchange factor, conserved site
Domain IPR000591 DEP domain
Domain IPR000595 Cyclic nucleotide-binding domain
Domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Family IPR008937 Ras-like guanine nucleotide exchange factor
Homologous_superfamily IPR014710 RmlC-like jelly roll fold
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR029071 Ubiquitin-like domain superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Homologous_superfamily IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily
Domain Details Per Protein
Protein Length Cyclic nucleotide-binding domain DEP domain Ras guanine-nucleotide exchange factor, catalytic domain superfamily Ras guanine-nucleotide exchange factor, conserved site Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor Ras-like guanine nucleotide exchange factor, N-terminal RmlC-like jelly roll fold Ubiquitin-like domain superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1QWC5 824
UniProtKB:E7FDC9 867
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations