Gene

npnta

ID

ZDB-GENE-090312-201

Name

nephronectin a

Symbol

npnta Nomenclature History

Previous Names

npnt
si:ch211-202n8.2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity. Acts upstream of or within atrioventricular valve development and heart trabecula formation. Predicted to be located in membrane. Is expressed in several structures, including digestive system; endoderm; head; heart; and tail bud. Used to study membranous glomerulonephritis and proteinuria. Orthologous to human NPNT (nephronectin).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

5 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 10 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With npnta Human Ortholog

No data available

Associated With npnta Via Experimental Models

Human Disease	Fish	Conditions	Citations
proteinuria	WT + MO2-npnta	standard conditions	Müller-Deile et al., 2017
membranous glomerulonephritis	WT + MO2-npnta	standard conditions	Müller-Deile et al., 2017

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000998	MAM domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR024731	EGF domain
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR052235	Nephronectin domain-containing protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Length	Concanavalin A-like lectin/glucanase domain superfamily	EGF domain	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	MAM domain	Nephronectin domain-containing protein	NOTCH1 EGF-like calcium-binding domain
UniProtKB:A0A8M2B6Z0 InterPro	619
UniProtKB:A0A8M3AVI7 InterPro	588
UniProtKB:B8A5G4 InterPro	605
UniProtKB:A0A8M3B3H9 InterPro	636

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	npnt-201 (1) Ensembl	Ensembl	2,441 nt	Select Tool ZFIN BLAST
mRNA	npnt-202 (1) Ensembl	Ensembl	431 nt	Select Tool ZFIN BLAST
mRNA	npnta-204 (1) Ensembl	Ensembl	1,907 nt	Select Tool ZFIN BLAST
mRNA	npnta-205 (1) Ensembl	Ensembl	1,856 nt	Select Tool ZFIN BLAST
ncRNA	npnt-003 (1) Ensembl	Ensembl	547 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations