Gene
gsk3bb
- ID
- ZDB-GENE-090312-2
- Name
- glycogen synthase kinase 3 beta, genome duplicate b
- Symbol
- gsk3bb Nomenclature History
- Previous Names
-
- si:dkeyp-80c12.7
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity and tau-protein kinase activity. Predicted to be involved in several processes, including insulin receptor signaling pathway; negative regulation of signal transduction; and positive regulation of catabolic process. Predicted to act upstream of or within several processes, including Wnt signaling pathway; protein phosphorylation; and rhythmic process. Predicted to be located in plasma membrane. Predicted to be part of beta-catenin destruction complex. Predicted to be active in several cellular components, including axon; cytosol; and glutamatergic synapse. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; oral squamous cell carcinoma; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR039192 | Glycogen synthase kinase 3, catalytic domain |
| Family | IPR050591 | Glycogen Synthase Kinase-3 |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Glycogen Synthase Kinase-3 | Glycogen synthase kinase 3, catalytic domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8JIQ1 | InterPro | 419 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
gsk3b (1 of many)-201
(1)
|
Ensembl | 1,260 nt | ||
| ncRNA |
si:dkeyp-80c12.7-002
(1)
|
Ensembl | 428 nt |
Interactions and Pathways
No data available
Plasmids
No data available