Gene

gsk3bb

ID

ZDB-GENE-090312-2

Name

glycogen synthase kinase 3 beta, genome duplicate b

Symbol

gsk3bb Nomenclature History

Previous Names

si:dkeyp-80c12.7

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Is predicted to enable beta-catenin binding activity; protein serine/threonine kinase activity; and tau-protein kinase activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of canonical Wnt signaling pathway; and regulation of microtubule cytoskeleton organization. Acts upstream of or within protein phosphorylation and rhythmic process. Predicted to be located in plasma membrane. Predicted to be part of beta-catenin destruction complex. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3B (glycogen synthase kinase 3 beta).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With gsk3bb Human Ortholog

No data available

Associated With gsk3bb Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008271	Serine/threonine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR039192	Glycogen synthase kinase 3, catalytic domain
Family	IPR033573	Glycogen synthase kinase-3 beta
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily

Domain Details Per Protein

Protein	Length	Glycogen synthase kinase-3 beta	Glycogen synthase kinase 3, catalytic domain	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine/threonine-protein kinase, active site
UniProtKB:B8JIQ1 InterPro	419

Transcripts

Genome Browsers

Type	Name	Length (nt)	Analysis
mRNA	gsk3b (1 of many)-201 (1) Ensembl	1260 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	si:dkeyp-80c12.7-002 (1) Ensembl	428 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations