Gene
chst3a
- ID
- ZDB-GENE-090312-180
- Name
- carbohydrate (chondroitin 6) sulfotransferase 3a
- Symbol
- chst3a Nomenclature History
- Previous Names
-
- si:ch211-232k3.6
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable N-acetylglucosamine 6-O-sulfotransferase activity and chondroitin 6-sulfotransferase activity. Predicted to be involved in N-acetylglucosamine metabolic process and chondroitin sulfate biosynthetic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be located in Golgi membrane. Is expressed in head; pectoral fin; pharyngeal arch cartilage; and somite. Human ortholog(s) of this gene implicated in osteochondrodysplasia and spondyloepiphyseal dysplasia with congenital joint dislocations. Orthologous to human CHST3 (carbohydrate sulfotransferase 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Habicher et al., 2015
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepiphyseal dysplasia with congenital joint dislocations | Alliance | Spondyloepiphyseal dysplasia with congenital joint dislocations | 143095 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Carbohydrate sulfotransferase | Gal/GlcNAc/GalNAc Sulfotransferase | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|---|---|
| UniProtKB:B8A5X2 | InterPro | 416 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
chst3a-201
(1)
|
Ensembl | 1,459 nt | ||
| mRNA |
chst3a-202
(1)
|
Ensembl | 1,808 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-232K3 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145571 (1) | |||
| Genomic | GenBank:BX855592 (1) | 159646 nt | ||
| Polypeptide | UniProtKB:B8A5X2 (1) | 416 aa |
- Habicher, J., Varshney, G.K., Waldmann, L., Snitting, D., Allalou, A., Zhang, H., Ghanem, A., Öhman Mägi, C., Dierker, T., Kjellén, L., Burgess, S.M., Ledin, J. (2022) Chondroitin/dermatan sulfate glycosyltransferase genes are essential for craniofacial development. PLoS Genetics. 18:e1010067
- Flanagan-Steet, H., Christian, C., Lu, P.N., Aarnio-Peterson, M., Sanman, L., Archer-Hartmann, S., Azadi, P., Bogyo, M., Steet, R.A. (2018) TGF-ß Regulates Cathepsin Activation during Normal and Pathogenic Development. Cell Reports. 22:2964-2977
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Habicher, J., Haitina, T., Eriksson, I., Holmborn, K., Dierker, T., Ahlberg, P.E., Ledin, J. (2015) Chondroitin / dermatan sulfate modification enzymes in zebrafish development. PLoS One. 10:e0121957
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