Gene
limch1a
- ID
- ZDB-GENE-090312-153
- Name
- LIM and calponin homology domains 1a
- Symbol
- limch1a Nomenclature History
- Previous Names
-
- si:ch211-157h5.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable myosin II head/neck binding activity. Predicted to be involved in positive regulation of stress fiber assembly and regulation of focal adhesion assembly. Predicted to act upstream of or within actomyosin structure organization. Predicted to be active in stress fiber. Is expressed in trunk vasculature. Orthologous to human LIMCH1 (LIM and calponin homology domains 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Kartopawiro et al., 2014
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa15501 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa16015 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa31201 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa44508 | Allele with one point mutation | Unknown | Unknown | ENU | |
| zko360b | Allele with one deletion | Unknown | Unknown | CRISPR |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-limch1a | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | Calponin/LIMCH1 | CH domain superfamily | Domain of unknown function DUF4757 | Smooth muscle protein/calponin | Zinc finger, LIM-type |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PV51 | InterPro | 1844 | ||||||
| UniProtKB:A0A8M9PHW0 | InterPro | 1960 | ||||||
| UniProtKB:A0A8M2BFN7 | InterPro | 1057 | ||||||
| UniProtKB:A0A8M9Q153 | InterPro | 1068 | ||||||
| UniProtKB:A0A8M2BG98 | InterPro | 1138 | ||||||
| UniProtKB:B8A4X7 | InterPro | 1019 | ||||||
| UniProtKB:A0A8M9PV53 | InterPro | 1572 | ||||||
| UniProtKB:A0A8M9QBW7 | InterPro | 1854 | ||||||
| UniProtKB:A0AB13AA78 | InterPro | 1931 | ||||||
| UniProtKB:A0AB32TKX9 | InterPro | 1967 | ||||||
| UniProtKB:A0AB32TME5 | InterPro | 1938 | ||||||
| UniProtKB:A0AB32TNC8 | InterPro | 1929 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
limch1a-201
(1)
|
Ensembl | 3,454 nt | ||
| ncRNA |
limch1a-002
(1)
|
Ensembl | 931 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-157H5 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001430852 (1) | 10167 nt | ||
| Genomic | GenBank:BX323984 (1) | 177080 nt | ||
| Polypeptide | UniProtKB:A0AB32TKX9 (1) | 1967 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Kartopawiro, J., Bower, N.I., Karnezis, T., Kazenwadel, J., Betterman, K.L., Lesieur, E., Koltowska, K., Astin, J., Crosier, P., Vermeren, S., Achen, M.G., Stacker, S.A., Smith, K.A., Harvey, N.L., François, M., and Hogan, B.M. (2014) Arap3 is dysregulated in a mouse model of hypotrichosis-lymphedema-telangiectasia and regulates lymphatic vascular development. Human molecular genetics. 23(5):1286-97
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