Gene
cnn1a
- ID
- ZDB-GENE-090312-141
- Name
- calponin 1, basic, smooth muscle, a
- Symbol
- cnn1a Nomenclature History
- Previous Names
-
- si:dkey-121b10.6
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable actin filament binding activity. Predicted to be involved in actin filament organization. Predicted to act upstream of or within actomyosin structure organization. Predicted to be active in actin cytoskeleton. Is expressed in gut. Orthologous to human CNN1 (calponin 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zada et al., 2022
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Calponin homology domain | Calponin-like | Calponin/LIMCH1 | Calponin repeat | CH domain superfamily | Smooth muscle protein/calponin |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:B8A668 | InterPro | 287 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-121B10 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001145598 (1) | |||
| Genomic | GenBank:BX901942 (1) | 166521 nt | ||
| Polypeptide | UniProtKB:B8A668 (1) | 287 aa |
- Zhang, J., Liang, Y., Zeng, W., Gao, X., Wang, D., Mai, C., Lin, Z., Zhao, H., Li, X. (2024) Inducing aortic aneurysm/dissection in zebrafish: evaluating the efficacy of β-Aminopropionic Nitrile as a model. Animal cells and systems. 28:849284-92
- Zada, A., Zhao, Y., Halim, D., Windster, J., van der Linde, H.C., Glodener, J., Overkleeft, S., de Graaf, B.M., Verdijk, R.M., Brooks, A.S., Shepherd, I., Gao, Y., Burns, A.J., Hofstra, R.M.W., Alves, M.M. (2022) The long Filamin-a isoform is required for intestinal development and motility: implications for chronic intestinal pseudo-obstruction. Human molecular genetics. 32(1):151-160
- Sun, Y., Zhang, B., Luo, L., Shi, D.L., Wang, H., Cui, Z., Huang, H., Cao, Y., Shu, X., Zhang, W., Zhou, J., Li, Y., Du, J., Zhao, Q., Chen, J., Zhong, H., Zhong, T.P., Li, L., Xiong, J.W., Peng, J., Xiao, W., Zhang, J., Yao, J., Yin, Z., Mo, X., Peng, G., Zhu, J., Chen, Y., Zhou, Y., Liu, D., Pan, W., Zhang, Y., Ruan, H., Liu, F., Zhu, Z., Meng, A., ZAKOC Consortium (2019) Systematic genome editing of the genes on zebrafish Chromosome 1 by CRISPR/Cas9. Genome research. 30(1):118-26
- Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
- Lundquist, M.R., Storaska, A.J., Liu, T.C., Larsen, S.D., Evans, T., Neubig, R.R., Jaffrey, S.R. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. Cell. 156(3):563-76
- Nolte, H., Konzer, A., Ruhs, A., Jungblut, B., Braun, T., Krüger, M. (2014) Global protein expression profiling of zebrafish organs based on in vivo incorporation of stable isotopes. Journal of Proteome Research. 13:2162-74
- Hultqvist, G., Daza, D.O., Larhammar, D., and Kilimann, M.W. (2012) Evolution of the vertebrate paralemmin gene family: ancient origin of gene duplicates suggests distinct functions. PLoS One. 7(7):e41850
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