Gene

mcf2la

ID

ZDB-GENE-090312-122

Name

mcf.2 cell line derived transforming sequence-like a

Symbol

mcf2la Nomenclature History

Previous Names

mcf2l
si:dkey-269p14.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of Rho protein signal transduction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be active in cytoplasm. Predicted to be extrinsic component of membrane. Is expressed in several structures, including Kupffer's vesicle; chondrocyte; immature eye; mandibular arch skeleton; and yolk syncytial layer. Orthologous to human MCF2L (MCF.2 cell line derived transforming sequence like).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Mitchell et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mcf2la Human Ortholog

No data available

Associated With mcf2la Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR001251	CRAL-TRIO lipid binding domain
Domain	IPR001452	SH3 domain
Domain	IPR001849	Pleckstrin homology domain
Domain	IPR035532	DBS, SH3 domain
Domain	IPR035534	DBS, PH domain
Family	IPR051336	Rho GTPase-activating Guanine Nucleotide Exchange Factors
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036028	SH3-like domain superfamily
Homologous_superfamily	IPR036865	CRAL-TRIO lipid binding domain superfamily

Domain Details Per Protein

Protein	Length	CRAL-TRIO lipid binding domain	CRAL-TRIO lipid binding domain superfamily	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	DBS, PH domain	DBS, SH3 domain	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PH-like domain superfamily	Pleckstrin homology domain	Rho GTPase-activating Guanine Nucleotide Exchange Factors	SH3 domain	SH3-like domain superfamily
UniProtKB:A0A8M9Q0I6 InterPro	1182
UniProtKB:A0A8M2BIA4 InterPro	1167
UniProtKB:A0A8M9QAY2 InterPro	1221
UniProtKB:A0A8M9QG01 InterPro	1206
UniProtKB:A0A8M9QG32 InterPro	1034
UniProtKB:A0A8M9QAZ1 InterPro	1191
UniProtKB:A0A8M2BID6 InterPro	1196
UniProtKB:A0A8M9QB00 InterPro	1191
UniProtKB:A0A8M1QR18 InterPro	1142

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	mcf2la-201 (1) Ensembl	Ensembl	4,010 nt	Select Tool ZFIN BLAST
mRNA	mcf2la-203 (1) Ensembl	Ensembl	637 nt	Select Tool ZFIN BLAST
mRNA	mcf2la-204 (1) Ensembl	Ensembl	3,541 nt	Select Tool ZFIN BLAST
ncRNA	mcf2la-003 (1) Ensembl	Ensembl	195 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations