megf6a

ID

ZDB-GENE-090312-12

Name

multiple EGF-like-domains 6a

Symbol

megf6a Nomenclature History

Previous Names

si:dkey-25b23.2 (1)

Type

protein_coding_gene

Location

Chr: 23 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Acts upstream of or within caudal fin morphogenesis and ossification involved in bone maturation. Predicted to be located in cell periphery. Is expressed in apical ectodermal ridge pectoral fin bud; head; notochord; and presumptive atrioventricular canal. Orthologous to human MEGF6 (multiple EGF like domains 6).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Teerlink et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With megf6a Human Ortholog

No data available

Associated With megf6a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR002049	Laminin-type EGF domain
Domain	IPR011489	EMI domain
Domain	IPR013111	Epidermal growth factor-like domain, extracellular
Domain	IPR049883	NOTCH1, EGF-like calcium-binding domain
Family	IPR052108	Multiple EGF-like domains/Integrin beta-like
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:A0A8M9PWW0	InterPro	1513
UniProtKB:A0A8M6Z4L7	InterPro	1513
UniProtKB:A0A8M9Q7W7	InterPro	1456
UniProtKB:A0A8M3AYG1	InterPro	1456
UniProtKB:A0AB32TE46	InterPro	1526
UniProtKB:A0AB32TEM4	InterPro	1469
UniProtKB:A0AB32TH19	InterPro	1526
UniProtKB:A0AB32TH21	InterPro	1469
UniProtKB:A0AC58ILA8	InterPro	1290
UniProtKB:A0AC58ILA9	InterPro	1370
UniProtKB:A0AC58ILB0	InterPro	1290
UniProtKB:A0AC58ILB1	InterPro	1383
UniProtKB:A0AC58ILB3	InterPro	1456
UniProtKB:A0AC58ILB5	InterPro	1302
UniProtKB:A0AC58ILB8	InterPro	1277
UniProtKB:A0AC58ILB9	InterPro	1289
UniProtKB:A0AC58ILC0	InterPro	1427
UniProtKB:A0AC58ILC4	InterPro	1416
UniProtKB:A0AC58ILC9	InterPro	1515
UniProtKB:A0AC58ILE0	InterPro	1513
UniProtKB:A0AC58ILE3	InterPro	932
UniProtKB:A0AC58ILE7	InterPro	1502
UniProtKB:A0AC58ILF0	InterPro	1277
UniProtKB:A0AC58ILI9	InterPro	951