ZFIN is now using GRCz12tu for Genomic Data
Gene
dnah12
- ID
- ZDB-GENE-090311-9
- Name
- dynein, axonemal, heavy chain 12
- Symbol
- dnah12 Nomenclature History
- Previous Names
-
- si:ch73-289a15.4
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable dynein intermediate chain binding activity; dynein light intermediate chain binding activity; and minus-end-directed microtubule motor activity. Predicted to be involved in cilium movement involved in cell motility. Predicted to act upstream of or within microtubule-based movement. Predicted to be located in cilium; cytoplasm; and microtubule. Predicted to be part of inner dynein arm. Predicted to be active in 9+2 motile cilium. Orthologous to human DNAH12 (dynein axonemal heavy chain 12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Spermatogenic failure 100 | 621209 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003593 | AAA+ ATPase domain |
| Domain | IPR004273 | Dynein heavy chain region D6 P-loop domain |
| Domain | IPR013602 | Dynein heavy chain, linker |
| Domain | IPR024317 | Dynein heavy chain, AAA module D4 |
| Domain | IPR024743 | Dynein heavy chain, coiled coil stalk |
| Domain | IPR035699 | Dynein heavy chain, hydrolytic ATP-binding dynein motor region |
| Domain | IPR035706 | Dynein heavy chain, ATP-binding dynein motor region |
| Domain | IPR041228 | Dynein heavy chain, C-terminal domain |
| Domain | IPR041466 | Dynein heavy chain, AAA 5 extension domain |
| Domain | IPR041589 | Dynein heavy chain 3, AAA+ lid domain |
| Domain | IPR041658 | Dynein heavy chain AAA lid domain |
| Family | IPR026983 | Dynein heavy chain |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR042219 | Dynein heavy chain AAA lid domain superfamily |
| Homologous_superfamily | IPR042222 | Dynein heavy chain, domain 2, N-terminal |
| Homologous_superfamily | IPR042228 | Dynein heavy chain, linker, subdomain 3 |
| Homologous_superfamily | IPR043157 | Dynein heavy chain, AAA1 domain, small subdomain |
| Homologous_superfamily | IPR043160 | Dynein heavy chain, C-terminal domain, barrel region |
Domain Details Per Protein
| Protein | Additional Resources | Length | AAA+ ATPase domain | Dynein heavy chain | Dynein heavy chain 3, AAA+ lid domain | Dynein heavy chain, AAA1 domain, small subdomain | Dynein heavy chain, AAA 5 extension domain | Dynein heavy chain AAA lid domain | Dynein heavy chain AAA lid domain superfamily | Dynein heavy chain, AAA module D4 | Dynein heavy chain, ATP-binding dynein motor region | Dynein heavy chain, coiled coil stalk | Dynein heavy chain, C-terminal domain | Dynein heavy chain, C-terminal domain, barrel region | Dynein heavy chain, domain 2, N-terminal | Dynein heavy chain, hydrolytic ATP-binding dynein motor region | Dynein heavy chain, linker | Dynein heavy chain, linker, subdomain 3 | Dynein heavy chain region D6 P-loop domain | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9PZ60 | InterPro | 3969 | ||||||||||||||||||
| UniProtKB:A0A8M9Q7R5 | InterPro | 3220 | ||||||||||||||||||
| UniProtKB:A0A8M9P5E8 | InterPro | 3969 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
dnah12-201
(1)
|
Ensembl | 11,637 nt | ||
| mRNA |
dnah12-202
(1)
|
Ensembl | 12,060 nt | ||
| mRNA |
dnah12-203
(1)
|
Ensembl | 8,904 nt | ||
| mRNA |
dnah12-204
(1)
|
Ensembl | 8,964 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers