Gene
plxna2
- ID
- ZDB-GENE-090311-6
- Name
- plexin A2
- Symbol
- plxna2 Nomenclature History
- Previous Names
-
- si:dkey-164k14.1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable semaphorin receptor activity. Acts upstream of or within optic vesicle formation. Predicted to be located in membrane. Predicted to be part of semaphorin receptor complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; hatching gland; nervous system; olfactory field; and optic vesicle. Orthologous to human PLXNA2 (plexin A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 12 figures from 5 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la028548Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa12731 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37759 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-plxna2 | van der Klaauw et al., 2019 | |
| CRISPR2-plxna2 | van der Klaauw et al., 2019 | |
| MO1-plxna2 | N/A | (4) |
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Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR002909 | IPT domain |
| Domain | IPR013548 | Plexin, cytoplasmic RasGAP domain |
| Domain | IPR016201 | PSI domain |
| Domain | IPR041019 | Plexin, TIG domain 1 |
| Domain | IPR041362 | Plexin, TIG domain 2 |
| Domain | IPR046800 | Plexin, cytoplasmic RhoGTPase-binding domain |
| Family | IPR031148 | Plexin family |
| Homologous_superfamily | IPR008936 | Rho GTPase activation protein |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR014756 | Immunoglobulin E-set |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
| Repeat | IPR002165 | Plexin repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Immunoglobulin E-set | Immunoglobulin-like fold | IPT domain | Plexin, cytoplasmic RasGAP domain | Plexin, cytoplasmic RhoGTPase-binding domain | Plexin family | Plexin repeat | Plexin, TIG domain 1 | Plexin, TIG domain 2 | PSI domain | Rho GTPase activation protein | Sema domain | Sema domain superfamily | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QPJ6 | InterPro | 1902 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
plxna2-201
(1)
|
Ensembl | 5,553 nt | ||
| mRNA |
plxna2-202
(1)
|
Ensembl | 6,103 nt | ||
| mRNA |
plxna2-203
(1)
|
Ensembl | 6,391 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-164K14 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-247P15 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-261H17 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_684688 (1) | 7383 nt | ||
| Genomic | GenBank:CR678070 (1) | 258381 nt | ||
| Polypeptide | UniProtKB:A0A2R8QPJ6 (1) | 1902 aa |
- Banu, S., Gaur, N., Nair, S., Ravikrishnan, T., Khan, S., Mani, S., Bharathi, S., Mandal, K., Kuram, N.A., Vuppaladadium, S., Ravi, R., Murthy, C.L.N., Quoseena, M., Babu, N.S., Idris, M.M. (2022) Transcriptomic and proteomic analysis of epimorphic regeneration in zebrafish caudal fin tissue. Genomics. 114(2):110300
- Zheng, Y.Q., Suo, G.H., Liu, D., Li, H.Y., Wu, Y.J., Ni, H. (2022) Nexmifa Regulates Axon Morphogenesis in Motor Neurons in Zebrafish. Frontiers in molecular neuroscience. 15:848257
- Garcia-Concejo, A., Larhammar, D. (2021) Protein kinase C family evolution in jawed vertebrates. Developmental Biology. 479:77-90
- Emerson, S.E., Stergas, H.R., Bupp-Chickering, S.O., Ebert, A.M. (2020) Shootin-1 Is Required for Nervous System Development in Zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 249(10):1285-1295
- van der Klaauw, A.A., Croizier, S., Mendes de Oliveira, E., Stadler, L.K.J., Park, S., Kong, Y., Banton, M.C., Tandon, P., Hendricks, A.E., Keogh, J.M., Riley, S.E., Papadia, S., Henning, E., Bounds, R., Bochukova, E.G., Mistry, V., O'Rahilly, S., Simerly, R.B., INTERVAL, UK10K Consortium, Minchin, J.E.N., Barroso, I., Jones, E.Y., Bouret, S.G., Farooqi, I.S. (2019) Human Semaphorin 3 Variants Link Melanocortin Circuit Development and Energy Balance. Cell. 176(4):729-742.e18
- Swaminathan, A., Hassan-Abdi, R., Renault, S., Siekierska, A., Riché, R., Liao, M., de Witte, P.A.M., Yanicostas, C., Soussi-Yanicostas, N., Drapeau, P., Samarut, É. (2018) Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development. Current biology : CB. 28(12):1924-1937.e5
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Emerson, S.E., Light, S.E., Ebert, A.M. (2017) Neuronal expression patterns of the PlexinA family during zebrafish development. Gene expression patterns : GEP. 27:56-66
- Emerson, S.E., St Clair, R.M., Waldron, A.L., Bruno, S.R., Duong, A., Driscoll, H.E., Ballif, B.A., McFarlane, S., Ebert, A.M. (2017) Identification of target genes downstream of Semaphorin6A/PlexinA2 signaling in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 246(7):539-549
- St Clair, R.M., Emerson, S.E., D'Elia, K.P., Weir, M.E., Schmoker, A.M., Ebert, A.M., Ballif, B.A. (2017) Fyn-dependent phosphorylation of PlexinA1 and PlexinA2 at conserved tyrosines is essential for zebrafish eye development. The FEBS journal. 285(1):72-86
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