Gene
herc56.1
- ID
- ZDB-GENE-090311-56
- Name
- HECT and RLD domain containing E3 ubiquitin protein ligase 56.1
- Symbol
- herc56.1 Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Orthologous to several human genes including HERC5 (HECT and RLD domain containing E3 ubiquitin protein ligase 5).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-herc56.1 | China Zebrafish Resource Center (CZRC) |
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Human Disease
Domain, Family, and Site Summary
No data available
Domain Details Per Protein
| Protein | Additional Resources | Length |
|---|---|---|
| UniProtKB:A0A8M6YXZ8 | InterPro | 884 |
| UniProtKB:A0AB32TSH0 | InterPro | 992 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch73-190m4.1-201
(1)
|
Ensembl | 3,639 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-190M4 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-192D9 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_068221727 (1) | 4242 nt | ||
| Genomic | GenBank:CR788312 (1) | 177966 nt | ||
| Polypeptide | UniProtKB:A0AB32TSH0 (1) | 992 aa |
- Comparative Orthology
- Alliance
- Li, Y.L., Gong, X.Y., Qu, Z.L., Zhao, X., Dan, C., Sun, H.Y., An, L.L., Gui, J.F., Zhang, Y.B. (2023) Zebrafish HERC7c Acts as an Inhibitor of Fish IFN Response. International Journal of Molecular Sciences. 24(5):
- Levraud, J.P., Jouneau, L., Briolat, V., Laghi, V., Boudinot, P. (2019) IFN-Stimulated Genes in Zebrafish and Humans Define an Ancient Arsenal of Antiviral Immunity. Journal of immunology (Baltimore, Md. : 1950). 203(12):3361-3373
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Briolat, V., Jouneau, L., Carvalho, R., Palha, N., Langevin, C., Herbomel, P., Schwartz, O., Spaink, H.P., Levraud, J.P., Boudinot, P. (2014) Contrasted Innate Responses to Two Viruses in Zebrafish: Insights into the Ancestral Repertoire of Vertebrate IFN-Stimulated Genes. Journal of immunology (Baltimore, Md. : 1950). 192:4328-41
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