Gene

atp11a

ID

ZDB-GENE-090311-52

Name

ATPase phospholipid transporting 11A

Symbol

atp11a Nomenclature History

Previous Names

si:dkey-251i8.1

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in phospholipid translocation. Predicted to localize to several cellular components, including endoplasmic reticulum; recycling endosome; and trans-Golgi network. Orthologous to human ATP11A (ATPase phospholipid transporting 11A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

2 figures from Hawkey-Noble et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With atp11a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal dominant nonsyndromic deafness 84	Alliance	Deafness, autosomal dominant 84	619810
hypomyelinating leukodystrophy 24	Alliance	?Leukodystrophy, hypomyelinating, 24	619851
		?Auditory neuropathy, autosomal dominant 2	620384

Associated With atp11a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032630	P-type ATPase, C-terminal
Domain	IPR032631	P-type ATPase, N-terminal
Domain	IPR044492	P-type ATPase, haloacid dehalogenase domain
Family	IPR001757	P-type ATPase
Family	IPR006539	P-type ATPase, subfamily IV
Homologous_superfamily	IPR008250	P-type ATPase, A domain superfamily
Homologous_superfamily	IPR023214	HAD superfamily
Homologous_superfamily	IPR023298	P-type ATPase, transmembrane domain superfamily
Homologous_superfamily	IPR023299	P-type ATPase, cytoplasmic domain N
Homologous_superfamily	IPR036412	HAD-like superfamily
PTM	IPR018303	P-type ATPase, phosphorylation site

Domain Details Per Protein

Protein	Length	HAD-like superfamily	HAD superfamily	P-type ATPase	P-type ATPase, A domain superfamily	P-type ATPase, C-terminal	P-type ATPase, cytoplasmic domain N	P-type ATPase, haloacid dehalogenase domain	P-type ATPase, N-terminal	P-type ATPase, phosphorylation site	P-type ATPase, subfamily IV	P-type ATPase, transmembrane domain superfamily
UniProtKB:A0A8M2BIA1 InterPro	1212
UniProtKB:A0A8M9Q0D9 InterPro	1204
UniProtKB:F8W2B0 InterPro	1177
UniProtKB:A0A8M2BIB5 InterPro	1145
UniProtKB:A0A8M9Q0F1 InterPro	1145
UniProtKB:A0A8M2BI82 InterPro	1177
UniProtKB:A0A8M9QFY8 InterPro	1149
UniProtKB:A0A8N7TDX5 InterPro	1137
UniProtKB:A0A8M9QFZ2 InterPro	1137
UniProtKB:A0A8M9Q0D3 InterPro	1212
UniProtKB:A0A8M2BIQ7 InterPro	1204

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	atp11a-201 (1) Ensembl	Ensembl	1,917 nt	Select Tool ZFIN BLAST
mRNA	atp11a-203 (1) Ensembl	Ensembl	3,375 nt	Select Tool
mRNA	atp11a-204 (1) Ensembl	Ensembl	10,460 nt	Select Tool
mRNA	atp11a-205 (1) Ensembl	Ensembl	3,456 nt	Select Tool ZFIN BLAST
ncRNA	atp11a-002 (1) Ensembl	Ensembl	462 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations