mapk8ip3

ID

ZDB-GENE-090303-6

Name

mitogen-activated protein kinase 8 interacting protein 3

Symbol

mapk8ip3 Nomenclature History

Previous Names

jip3 (1)
JNK-interacting protein 3 (1)

Type

protein_coding_gene

Location

Chr: 3 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Enables cargo adaptor activity. Acts upstream of or within regulation of JNK cascade and retrograde axonal protein transport. Predicted to be located in several cellular components, including Golgi apparatus; growth cone; and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Is expressed in central nervous system; peripheral nervous system; and posterior lateral line ganglion. Orthologous to human MAPK8IP3 (mitogen-activated protein kinase 8 interacting protein 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Drerup et al., 2013

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 11 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mapk8ip3 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with or without variable brain abnormalities	618443

Associated With mapk8ip3 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR032486	JNK-interacting protein, leucine zipper II
Domain	IPR034743	RH1 domain
Domain	IPR034744	RH2 domain
Family	IPR039911	JNK-interacting protein 3/4
Homologous_superfamily	IPR015943	WD40/YVTN repeat-like-containing domain superfamily
Homologous_superfamily	IPR036322	WD40-repeat-containing domain superfamily

Domain Details Per Protein

Protein	Additional Resources	Length
UniProtKB:L7RKJ8	InterPro	1299
UniProtKB:A0AB13A9J8	InterPro	1311
UniProtKB:A0AB13AB31	InterPro	1334
UniProtKB:A0AB13ABF1	InterPro	1275
UniProtKB:A0A8M1P724	InterPro	1300
UniProtKB:A0AC58IA29	InterPro	1336
UniProtKB:A0AC58IA36	InterPro	1336
UniProtKB:A0AC58IA37	InterPro	1342
UniProtKB:A0AC58IA39	InterPro	1331
UniProtKB:A0AC58IA50	InterPro	1329
UniProtKB:A0AC58IA51	InterPro	1324
UniProtKB:A0AC58IA61	InterPro	1325
UniProtKB:A0AC58IA71	InterPro	1321
UniProtKB:A0AC58IA76	InterPro	1318
UniProtKB:A0AC58IA78	InterPro	1305
UniProtKB:A0AC58IA83	InterPro	1319
UniProtKB:A0AC58IA84	InterPro	1303
UniProtKB:A0AC58IA86	InterPro	1277
UniProtKB:A0AC58IA90	InterPro	1323
UniProtKB:A0AC58IA92	InterPro	1282
UniProtKB:A0AC58IA94	InterPro	1312
UniProtKB:A0AC58IA98	InterPro	1284
UniProtKB:A0AC58IAA2	InterPro	1288
UniProtKB:A0AC58IAA3	InterPro	973
UniProtKB:A0AC58IAA4	InterPro	973
UniProtKB:A0AC58IAA5	InterPro	1295
UniProtKB:A0AC58IAA8	InterPro	1290
UniProtKB:A0AC58IAC1	InterPro	973
UniProtKB:A0AC58IAC2	InterPro	1271
UniProtKB:A0AC58IAC4	InterPro	973
UniProtKB:A0AC58IAD8	InterPro	960
UniProtKB:A0AC58IAE9	InterPro	1323
UniProtKB:A0AC58IAF1	InterPro	962
UniProtKB:A0AC58IAF2	InterPro	929
UniProtKB:A0AC58IAG6	InterPro	956
UniProtKB:A0AC58IAG8	InterPro	1311
UniProtKB:A0AC58IAI3	InterPro	1292