Gene
trpm4a
- ID
- ZDB-GENE-090302-3
- Name
- transient receptor potential cation channel, subfamily M, member 4a
- Symbol
- trpm4a Nomenclature History
- Previous Names
-
- trpm4 (1)
- sb:eu515
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Enables calcium-activated cation channel activity. Predicted to be involved in metal ion transport and monoatomic cation transmembrane transport. Predicted to act upstream of or within monoatomic ion transport and transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in brain; digestive system; integument; keratinocyte; and posterior pronephric duct. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis et progressiva 6 and progressive familial heart block type IB. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu515 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| erythrokeratodermia variabilis et progressiva 6 | Alliance | Erythrokeratodermia variabilis et progressiva 6 | 618531 |
| progressive familial heart block type IB | Alliance | Progressive familial heart block, type IB | 604559 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Ion transport domain | Transient receptor potential cation channel M | TRPM, SLOG domain |
|---|---|---|---|---|---|
| UniProtKB:S5TRY1 | InterPro | 1260 | |||
| UniProtKB:A0A8M2BBK8 | InterPro | 766 | |||
| UniProtKB:A0A8M9PCR1 | InterPro | 1031 | |||
| UniProtKB:A0A8M2BB87 | InterPro | 930 | |||
| UniProtKB:A0A8M1P6E5 | InterPro | 1260 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
trpm4a-201
(1)
|
Ensembl | 4,659 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-367P23 | ZFIN Curated Data | |
| Contained in | BAC | CH73-378O21 | ZFIN Curated Data | |
| Contained in | BAC | DKEY-259B21 | ZFIN Curated Data | |
| Encodes | EST | eu515 | Thisse et al., 2005 |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001288815 (1) | 4041 nt | ||
| Genomic | GenBank:FP236454 (1) | 80694 nt | ||
| Polypeptide | UniProtKB:A0A8M1P6E5 (1) | 1260 aa |
- Gross-Thebing, S., Truszkowski, L., Tenbrinck, D., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, B.E., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., Raz, E. (2020) Using migrating cells as probes to illuminate features in live embryonic tissues. Science advances. 6(49):
- You, M.S., Yang, W.B., Cheng, C.H., Yu, S., Chang, H.C., Yu, H.S. (2020) Red LED light treatment promotes cognitive learning through up-regulation of trpm4 in zebrafish. Journal of photochemistry and photobiology. B, Biology. 213:112073
- Jerônimo, R., Moraes, M.N., de Assis, L.V.M., Ramos, B.C., Rocha, T., Castrucci, A.M.L. (2017) Thermal stress in Danio rerio: a link between temperature, light, thermo-TRP channels, and clock genes. Journal of thermal biology. 68:128-138
- Rabinowitz, J.S., Robitaille, A.M., Wang, Y., Ray, C.A., Thummel, R., Gu, H., Djukovic, D., Raftery, D., Berndt, J.D., Moon, R.T. (2017) Transcriptomic, proteomic, and metabolomic landscape of positional memory in the caudal fin of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 114(5):E717-E726
- Cheng, H., Ellis, J., Kleinow, K.M. (2015) Expression and functionality of transient receptor potential melastatin 4 (TRPM4)-like channels during development of the zebrafish. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 178:33-44
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Graham, D.M., Huang, L., Robinson, K.R., and Messerli, M.A. (2013) Epidermal keratinocyte polarity and motility require Ca2+ influx through TRPV1. Journal of Cell Science. 126(Pt 20):4602-13
- Kastenhuber, E., Gesemann, M., Mickoleit, M., and Neuhauss, S.C. (2013) Phylogenetic analysis and expression of zebrafish transient receptor potential melastatin family genes. Developmental Dynamics : an official publication of the American Association of Anatomists. 242(11):1236-49
- Saito, S., and Shingai, R. (2006) Evolution of thermoTRP ion channel homologs in vertebrates. Physiological Genomics. 27(3):219-230
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