Gene
trpm4a
- ID
- ZDB-GENE-090302-3
- Name
- transient receptor potential cation channel, subfamily M, member 4a
- Symbol
- trpm4a Nomenclature History
- Previous Names
-
- trpm4 (1)
- sb:eu515
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Exhibits calcium activated cation channel activity. Predicted to be involved in several processes, including cardiac conduction; regulation of T cell cytokine production; and vasoconstriction. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in erythrokeratodermia variabilis and progressive familial heart block type IB. Is expressed in brain; digestive system; integument; keratinocyte; and posterior pronephric duct. Orthologous to human TRPM4 (transient receptor potential cation channel subfamily M member 4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- eu515 (1 image)
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| erythrokeratodermia variabilis et progressiva 6 | Alliance | Erythrokeratodermia variabilis et progressiva 6 | 618531 |
| progressive familial heart block type IB | Alliance | Progressive familial heart block, type IB | 604559 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Ion transport domain | TRPM, SLOG domain |
|---|---|---|---|
|
UniProtKB:S5TRY1
|
1260 | ||
|
UniProtKB:A0A8M2BBK8
|
766 | ||
|
UniProtKB:A0A8M9PCR1
|
1031 | ||
|
UniProtKB:A0A8M2BB87
|
930 |
| Type | Name | Annotation Method | Length (nt) | Analysis |
|---|---|---|---|---|
| mRNA |
trpm4a-201
(1)
|
Havana | 4659 nt |
Interactions and Pathways
No data available
Plasmids
No data available