Gene
disc1
- ID
- ZDB-GENE-090122-1
- Name
- DISC1 scaffold protein
- Symbol
- disc1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Involved in several processes, including animal organ development; convergent extension involved in gastrulation; and oligodendrocyte cell fate specification. Human ortholog(s) of this gene implicated in autism spectrum disorder (multiple); bipolar disorder; chronic fatigue syndrome; major depressive disorder; and psychotic disorder (multiple). Is expressed in several structures, including cranial cartilage; immature eye; nervous system; neural crest; and notochord. Orthologous to human DISC1 (DISC1 scaffold protein).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 24 figures from 7 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| schizophrenia 9 | Alliance | {Schizophrenia 9, susceptibility to} | 604906 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR026081 | Disrupted in schizophrenia 1 |
Domain Details Per Protein
| Protein | Length | Disrupted in schizophrenia 1 |
|---|---|---|
|
UniProtKB:B8PWL7
|
994 |
Interactions and Pathways
No data available
Plasmids
No data available