Gene

igfbp2b

ID

ZDB-GENE-090107-3

Name

insulin-like growth factor binding protein 2b

Symbol

igfbp2b Nomenclature History

Previous Names

igfbp2a
si:ch211-2k18.3 (1)

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Enables insulin-like growth factor I binding activity. Involved in negative regulation of developmental growth. Acts upstream of or within sprouting angiogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in digestive system; kidney; muscle; and ovary. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (insulin like growth factor binding protein 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With igfbp2b Human Ortholog

No data available

Associated With igfbp2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017891	Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
Domain	IPR000716	Thyroglobulin type-1
Domain	IPR000867	Insulin-like growth factor-binding protein, IGFBP
Family	IPR012210	Insulin-like growth factor binding protein 2
Family	IPR022321	Insulin-like growth factor-binding protein family 1-6, chordata
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR036857	Thyroglobulin type-1 superfamily