Gene
prkaa2
- ID
- ZDB-GENE-081120-5
- Name
- protein kinase, AMP-activated, alpha 2 catalytic subunit
- Symbol
- prkaa2 Nomenclature History
- Previous Names
-
- ampka2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 20 Mapping Details/Browsers
- Description
- Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of TORC1 signaling; and protein localization to lipid droplet. Predicted to act upstream of or within several processes, including Wnt signaling pathway; cholesterol biosynthetic process; and protein phosphorylation. Predicted to be part of nucleotide-activated protein kinase complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Zang et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR028783 | PRKAA2, UBA-like autoinhibitory domain |
| Domain | IPR032270 | AMPK, C-terminal adenylate sensor domain |
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Domain Details Per Protein
| Protein | Additional Resources | Length | AMPK, C-terminal adenylate sensor domain | KA1 domain/Ssp2, C-terminal | PRKAA1/2, autoinhibitory domain | PRKAA2, UBA-like autoinhibitory domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:E7F9C4 | InterPro | 553 |
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- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
prkaa2-201
(1)
|
Ensembl | 3,579 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Bennoit, N.R., Craig, P.M. (2020) Increased metabolic rate associated with immune stimulation of heat-killed Vibrio anguillarum at different temperatures in zebrafish (Danio rerio). Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 250:110489
- Collodet, C., Foretz, M., Deak, M., Bultot, L., Metairon, S., Viollet, B., Lefebvre, G., Raymond, F., Parisi, A., Civiletto, G., Gut, P., Descombes, P., Sakamoto, K. (2019) AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33(11):12374-12391
- Zang, L., Shimada, Y., Nakayama, H., Kim, Y., Chu, D.C., Juneja, L.R., Kuroyanagi, J., Nishimura, N. (2019) RNA-seq Based Transcriptome Analysis of the Anti-Obesity Effect of Green Tea Extract Using Zebrafish Obesity Models. Molecules. 24(18)
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Craig, P.M., Trudeau, V.L., Moon, T.W. (2014) Profiling Hepatic microRNAs in Zebrafish: Fluoxetine Exposure Mimics a Fasting Response That Targets AMP-Activated Protein Kinase (AMPK). PLoS One. 9:e95351
- Mendelsohn, B.A., Kassebaum, B.L., and Gitlin, J.D. (2008) The zebrafish embryo as a dynamic model of anoxia tolerance. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(7):1780-1788
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