Gene

prkaa2

ID
ZDB-GENE-081120-5
Name
protein kinase, AMP-activated, alpha 2 catalytic subunit
Symbol
prkaa2 Nomenclature History
Previous Names
  • ampka2 (1)
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to have protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human PRKAA2 (protein kinase AMP-activated catalytic subunit alpha 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Zang et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prkaa2 Human Ortholog
No data available
Associated With prkaa2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR028783 PRKAA2, UBA-like autoinhibitory domain
Domain IPR032270 AMPK, C-terminal adenylate sensor domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR028375 KA1 domain/Ssp2, C-terminal
Domain Details Per Protein
Protein Length AMPK, C-terminal adenylate sensor domain KA1 domain/Ssp2, C-terminal PRKAA2, UBA-like autoinhibitory domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:E7F9C4 553
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations