frem2a

ID

ZDB-GENE-081119-3

Name

FRAS1 related extracellular matrix 2a

Symbol

frem2a Nomenclature History

Previous Names

bla (1)
blasen (1)

Type

protein_coding_gene

Location

Chr: 10 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable metal ion binding activity. Acts upstream of or within fin morphogenesis. Predicted to be located in membrane. Predicted to be active in extracellular matrix. Is expressed in fin; fin fold pectoral fin bud; median fin fold; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frem2a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Fraser syndrome 2	Alliance	Fraser syndrome 2	617666
isolated cryptophthalmia	Alliance	Cryptophthalmos, unilateral or bilateral, isolated	123570

Associated With frem2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR045658	FRAS1-related extracellular matrix protein, N-terminal domain
Family	IPR051561	FRAS1-related extracellular matrix
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Repeat	IPR039005	CSPG repeat