Gene

frem1a

ID
ZDB-GENE-081119-1
Name
Fras1 related extracellular matrix 1a
Symbol
frem1a Nomenclature History
Previous Names
  • rfl (1)
  • rafels (1)
Type
protein_coding_gene
Location
Chr: 7 Mapping Details/Browsers
Description
Involved in fin morphogenesis. Predicted to localize to integral component of membrane. Is expressed in fin fold pectoral fin bud; median fin fold; pectoral fin; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).
Genome Resources
Note
None
Expression
All Expression Data
3 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
17 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With frem1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Bifid nose with or without anorectal and renal anomalies 608980
Manitoba oculotrichoanal syndrome 248450
Trigonocephaly 2 614485
Associated With frem1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001304 C-type lectin-like
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Homologous_superfamily IPR016186 C-type lectin-like/link domain superfamily
Homologous_superfamily IPR016187 C-type lectin fold
Homologous_superfamily IPR038081 CalX-like domain superfamily
Repeat IPR039005 CSPG repeat
Domain Details Per Protein
Protein Length CalX-like domain superfamily CSPG repeat C-type lectin fold C-type lectin-like C-type lectin-like/link domain superfamily Na-Ca exchanger/integrin-beta4
UniProtKB:F1R4B2 2167
UniProtKB:B6IDE4 1685
UniProtKB:D7PS89 2167
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations