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ZIRC
ZFIN ID: ZDB-GENE-081119-1
Gene Name: Fras1 related extracellular matrix 1a
Gene Symbol: frem1a    Nomenclature History

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Previous Names: rfl (1), rafels (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Involved in fin morphogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Is expressed in fin fold pectoral fin bud; median fin fold; pectoral fin; pharyngeal arch; and trunk. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).
Genome Resources: Alliance (1),  Gene:100216326 (1),  Ensembl(GRCz11):ENSDARG00000069473 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fr23 Point Mutation Unknown Premature Stop ENU
la016230Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1148 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9531 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13110 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27100 Point Mutation Unknown Premature Stop ENU
    sa31619 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34238 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41083 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41084 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb233b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc228 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tc280b Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te217 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • te370b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tg308b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tm235b Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp66 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tp226 Unknown Unknown Unknown ENU
    tq266c Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tr240 Point Mutation Intron 32 Cryptic Acceptor Splice Site, Frameshift, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • tz245 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-frem1a N/A 1
    MO2-frem1a N/A 1
    DISEASE ASSOCIATED WITH frem1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Bifid nose with or without anorectal and renal anomalies 608980
    Manitoba oculotrichoanal syndrome 248450
    Trigonocephaly 2 614485
    DISEASE ASSOCIATED WITH frem1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 4)
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM frem1a No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001190308 (1)
    Genomic GenBank:CABZ01084443 (1) 1917 bp
    Polypeptide UniProtKB:D7PS89 (1) 2167 aa
    Sequence Clusters UniGene:159209 (1)
    Sequence Information (all 15)
    ORTHOLOGY for frem1a ( Chr: 7 )
    CITATIONS (23)