Gene

frem1a

ID

ZDB-GENE-081119-1

Name

Fras1 related extracellular matrix 1a

Symbol

frem1a Nomenclature History

Previous Names

rfl (1)
rafels (1)

Type

protein_coding_gene

Location

Chr: 7 Mapping Details/Browsers

Description

Involved in fin morphogenesis. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Is expressed in fin fold pectoral fin bud; median fin fold; pectoral fin; pharyngeal arch; and trunk. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

3 figures from 2 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With frem1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Bifid nose with or without anorectal and renal anomalies	608980
		Manitoba oculotrichoanal syndrome	248450
		Trigonocephaly 2	614485

Associated With frem1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001304	C-type lectin-like
Domain	IPR003644	Na-Ca exchanger/integrin-beta4
Domain	IPR045658	FRAS1-related extracellular matrix protein, N-terminal domain
Family	IPR051561	FRAS1-related extracellular matrix
Homologous_superfamily	IPR016186	C-type lectin-like/link domain superfamily
Homologous_superfamily	IPR016187	C-type lectin fold
Homologous_superfamily	IPR038081	CalX-like domain superfamily
Repeat	IPR039005	CSPG repeat

Domain Details Per Protein

Protein	Length	CalX-like domain superfamily	CSPG repeat	C-type lectin fold	C-type lectin-like	C-type lectin-like/link domain superfamily	FRAS1-related extracellular matrix	FRAS1-related extracellular matrix protein, N-terminal domain	Na-Ca exchanger/integrin-beta4
UniProtKB:D7PS89 InterPro	2167

Transcripts

Genome Browsers

NCBI

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	frem1a-201 (1) Ensembl	Ensembl		7,217 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations