Gene
sult1st7
- ID
- ZDB-GENE-081112-3
- Name
- sulfotransferase family 1, cytosolic sulfotransferase 7
- Symbol
- sult1st7 Nomenclature History
- Previous Names
-
- si:ch211-196g2.6
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Enables sulfotransferase activity. Predicted to be involved in sulfation. Predicted to act upstream of or within catecholamine metabolic process. Predicted to be active in cytoplasm. Is expressed in female organism. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; gastrointestinal system cancer (multiple); lung cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to several human genes including SULT1A1 (sulfotransferase family 1A member 1); SULT1A2 (sulfotransferase family 1A member 2); and SULT1A3 (sulfotransferase family 1A member 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Liu et al., 2008
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa7283 | Allele with one point mutation | Unknown | Splice Site, Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | Sulfotransferase domain |
|---|---|---|---|---|
| UniProtKB:F1RD72 | InterPro | 301 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sult1st7-201
(1)
|
Ensembl | 906 nt | ||
| mRNA |
sult1st7-202
(1)
|
Ensembl | 807 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-196G2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001139481 (1) | 1497 nt | ||
| Genomic | GenBank:AL935148 (1) | 195396 nt | ||
| Polypeptide | UniProtKB:F1RD72 (1) | 301 aa |
No data available
- Pottie, L., Van Gool, W., Vanhooydonck, M., Hanisch, F.G., Goeminne, G., Rajkovic, A., Coucke, P., Sips, P., Callewaert, B. (2021) Loss of zebrafish atp6v1e1b, encoding a subunit of vacuolar ATPase, recapitulates human ARCL type 2C syndrome and identifies multiple pathobiological signatures. PLoS Genetics. 17:e1009603
- Yamauchi, K., Katsumata, S., Ozaki, M. (2019) A prototype of the mammalian sulfotransferase 1 (SULT1) family in Xenopus laevis: molecular and enzymatic properties of XlSULT1B.S. Genes & genetic systems. 94(5):207-217
- Fent, K., Chew, G., Li, J., Gomez, E. (2014) Benzotriazole UV-stabilizers and benzotriazole: Antiandrogenic activity in vitro and activation of aryl hydrocarbon receptor pathway in zebrafish eleuthero-embryos. The Science of the total environment. 482-483:125-36
- Zucchi, S., Castiglioni, S., and Fent, K. (2013) Progesterone Alters Global Transcription Profiles at Environmental Concentrations in Brain and Ovary of Female Zebrafish (Danio rerio). Environmental science & technology. 47(21):12548-56
- Mohammed, Y.I., Kurogi, K., Shaban, A.A., Xu, Z., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., Bhuiyan, S., and Liu, M.C. (2012) Identification and characterization of zebrafish SULT1 ST9, SULT3 ST4, and SULT3 ST5. Aquatic toxicology (Amsterdam, Netherlands). 112-113C:11-18
- Kurogi, K., Dillon, J., Nasser, A., Liu, M.Y., Williams, F.E., Sakakibara, Y., Suiko, M., and Liu, M.C. (2010) Sulfation of Drug Compounds by the Zebrafish Cytosolic Sulfotransferases (SULTs). Drug metabolism letters. 4(2):62-68
- Liu, T.A., Bhuiyan, S., Snow, R., Yasuda, S., Yasuda, T., Yang, Y.S., Williams, F.E., Liu, M.Y., Suiko, M., Carter, G., and Liu, M.C. (2008) Identification and characterization of two novel cytosolic sulfotransferases, SULT1 ST7 and SULT1 ST8, from zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 89(2):94-102
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