Gene
rem2
- ID
- ZDB-GENE-081110-1
- Name
- RAS (RAD and GEM)-like GTP binding 2
- Symbol
- rem2 Nomenclature History
- Previous Names
-
- si:ch211-119o8.5
- Type
- protein_coding_gene
- Location
- Chr: 2 Mapping Details/Browsers
- Description
- Enables calcium channel regulator activity. Acts upstream of or within dopaminergic neuron differentiation. Predicted to be active in plasma membrane. Is expressed in eye and optic tectum. Orthologous to human REM2 (RRAD and GEM like GTPase 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Edel et al., 2010
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Edel et al., 2010
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la023672Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa38348 | Allele with one point mutation | Unknown | Splice Site | ENU |
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Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | P-loop containing nucleoside triphosphate hydrolase | RGK GTP-binding regulators | Small GTPase |
|---|---|---|---|---|---|
| UniProtKB:B0R168 | InterPro | 306 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-119O8 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001123046 (1) | 1569 nt | ||
| Genomic | GenBank:AL953896 (1) | 158018 nt | ||
| Polypeptide | UniProtKB:B0R168 (1) | 306 aa |
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Puhl, H.L., Lu, V.B., Won, Y.J., Sasson, Y., Hirsch, J.A., Ono, F., Ikeda, S.R. (2014) Ancient Origins of RGK Protein Function: Modulation of Voltage-Gated Calcium Channels Preceded the Protostome and Deuterostome Split. PLoS One. 9:e100694
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Hollis, D.M., Sawa, Y., Wagoner, A., Rawlings, J.S., and Goetz, F.W. (2012) Isolation and molecular characterization of Rem2 isoforms in the rainbow trout (Oncorhynchus mykiss): Tissue and central nervous system expression. Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology. 161(2):93-101
- Edel, M.J., Boué, S., Menchon, C., Sánchez-Danés, A., and Belmonte, J.C. (2010) Rem2 GTPase controls proliferation and apoptosis of neurons during embryo development. Cell cycle (Georgetown, Tex.). 9(17):3414-3422
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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