ZFIN is now using GRCz12tu for Genomic Data
Gene
prop1
- ID
- ZDB-GENE-081107-40
- Name
- PROP paired-like homeobox 1
- Symbol
- prop1 Nomenclature History
- Previous Names
-
- si:ch211-93n23.5 (1)
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within adenohypophysis development. Predicted to be located in nucleus. Is expressed in hypophysis. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Angotzi et al., 2011
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| combined pituitary hormone deficiency 2 | Alliance | Pituitary hormone deficiency, combined, 2 | 262600 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | Homedomain-like superfamily | Homeobox, conserved site | Homeobox protein prophet of Pit-1 | Homeodomain |
|---|---|---|---|---|---|---|
| UniProtKB:A0A2R8QKN2 | InterPro | 227 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers