Gene
ubr2
- ID
- ZDB-GENE-081107-29
- Name
- ubiquitin protein ligase E3 component n-recognin 2
- Symbol
- ubr2 Nomenclature History
- Previous Names
-
- si:ch211-239i4.2
- Type
- protein_coding_gene
- Location
- Chr: 13 Mapping Details/Browsers
- Description
- Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Is expressed in female organism. Orthologous to human UBR2 (ubiquitin protein ligase E3 component n-recognin 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Newman et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la011149Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa6283 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa14897 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa42121 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003126 | Zinc finger, UBR-type |
| Domain | IPR003769 | Adaptor protein ClpS, core |
| Domain | IPR044046 | E3 ubiquitin-protein ligase UBR-like, C-terminal |
| Domain | IPR047508 | E3 ubiquitin-protein ligase UBR2, UBR-box |
| Domain | IPR055194 | E3 ubiquitin-protein ligase UBR1-like, winged-helix domain |
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Domain Details Per Protein
| Protein | Length | Adaptor protein ClpS, core | E3 ubiquitin-protein ligase ELL-like | E3 ubiquitin-protein ligase UBR1-like | E3 ubiquitin-protein ligase UBR1-like, winged-helix domain | E3 ubiquitin-protein ligase UBR2, UBR-box | E3 ubiquitin-protein ligase UBR-like, C-terminal | Ribosomal protein bL12, C-terminal/adaptor protein ClpS-like | Winged helix DNA-binding domain superfamily | Zinc finger, UBR-type |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M2B2U0
|
1756 | |||||||||
|
UniProtKB:A0A8M9PB10
|
946 | |||||||||
|
UniProtKB:A0A8M6Z2H4
|
1770 | |||||||||
|
UniProtKB:A0A8M2B2K6
|
1757 | |||||||||
|
UniProtKB:A0A8M9PML5
|
546 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH73-193I2 | ZFIN Curated Data | |
| Contained in | BAC | CH211-239I4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_001921555 (1) | |||
| Genomic | GenBank:BX248117 (1) | 181542 nt | ||
| Polypeptide | UniProtKB:A0A8M6Z1W9 (1) | 1771 aa |
- Postlethwait, J.H., Massaquoi, M.S., Farnsworth, D.R., Yan, Y.L., Guillemin, K., Miller, A.C. (2021) The SARS-CoV-2 receptor and other key components of the Renin-Angiotensin-Aldosterone System related to COVID-19 are expressed in enterocytes in larval zebrafish. Biology Open. 10(3):
- Newman, M., Hin, N., Pederson, S., Lardelli, M. (2019) Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Molecular brain. 12:43
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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