Gene
iqsec2b
- ID
- ZDB-GENE-081105-73
- Name
- IQ motif and Sec7 domain ArfGEF 2b
- Symbol
- iqsec2b Nomenclature History
- Previous Names
-
- iqsec2
- si:ch211-218o21.3
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within regulation of ARF protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 1 | Alliance | Intellectual developmental disorder, X-linked 1 | 309530 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000904 | Sec7 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR033742 | IQ motif and SEC7 domain-containing protein, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
| Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
| Protein | Length | IQ motif and SEC7 domain-containing protein, PH domain | PH-like domain superfamily | Pleckstrin homology domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M1PUK2
|
1527 | ||||||
|
UniProtKB:A0A8M3BBZ0
|
1435 | ||||||
|
UniProtKB:A0A8M2BFA4
|
1095 | ||||||
|
UniProtKB:E9QDV4
|
1520 | ||||||
|
UniProtKB:A0A8M9PRI2
|
1574 | ||||||
|
UniProtKB:A0A8M2BEM6
|
1581 | ||||||
|
UniProtKB:A0A8M2BEK2
|
1101 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
iqsec2b-201
(1)
|
Ensembl | 7,955 nt | ||
| mRNA |
iqsec2b-202
(1)
|
Ensembl | 4,120 nt | ||
| mRNA |
iqsec2b-203
(1)
|
Ensembl | 8,267 nt |
Interactions and Pathways
No data available
Plasmids
No data available