Gene
iqsec2b
- ID
- ZDB-GENE-081105-73
- Name
- IQ motif and Sec7 domain ArfGEF 2b
- Symbol
- iqsec2b Nomenclature History
- Previous Names
-
- iqsec2
- si:ch211-218o21.3
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| non-syndromic X-linked intellectual disability 1 | Alliance | Intellectual developmental disorder, X-linked 1 | 309530 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000904 | Sec7 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR033742 | IQ motif and SEC7 domain-containing protein, PH domain |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR023394 | Sec7, C-terminal domain superfamily |
| Homologous_superfamily | IPR035999 | Sec7 domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | IQ motif and SEC7 domain-containing protein, PH domain | PH-like domain superfamily | Pleckstrin homology domain | Sec7, C-terminal domain superfamily | Sec7 domain | Sec7 domain superfamily |
|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1PUK2 | InterPro | 1527 | ||||||
| UniProtKB:A0A8M3BBZ0 | InterPro | 1435 | ||||||
| UniProtKB:A0A8M2BFA4 | InterPro | 1095 | ||||||
| UniProtKB:E9QDV4 | InterPro | 1520 | ||||||
| UniProtKB:A0A8M9PRI2 | InterPro | 1574 | ||||||
| UniProtKB:A0A8M2BEM6 | InterPro | 1581 | ||||||
| UniProtKB:A0A8M2BEK2 | InterPro | 1101 | ||||||
| UniProtKB:A0AB32TWE6 | InterPro | 1638 | ||||||
| UniProtKB:A0AB32TXB1 | InterPro | 1631 | ||||||
| UniProtKB:A0AB32TZ89 | InterPro | 1584 | ||||||
| UniProtKB:A0AB32TZQ9 | InterPro | 1152 | ||||||
| UniProtKB:A0AB32U0P5 | InterPro | 1577 | ||||||
| UniProtKB:A0AB32U1W7 | InterPro | 1158 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
iqsec2b-201
(1)
|
Ensembl | 7,955 nt | ||
| mRNA |
iqsec2b-202
(1)
|
Ensembl | 4,120 nt | ||
| mRNA |
iqsec2b-203
(1)
|
Ensembl | 8,267 nt |
Interactions and Pathways
No data available
Plasmids
No data available