Gene

rhobtb2a

ID
ZDB-GENE-081105-67
Name
Rho related BTB domain containing 2a
Symbol
rhobtb2a Nomenclature History
Previous Names
  • si:dkey-263f15.2
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to enable GTP binding activity; GTPase activity; and protein kinase binding activity. Predicted to be involved in several processes, including cytoskeleton organization; engulfment of apoptotic cell; and regulation of cell shape. Predicted to act upstream of or within small GTPase mediated signal transduction. Predicted to be active in several cellular components, including cell cortex; cytoplasmic vesicle; and cytoskeleton. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy. Orthologous to human RHOBTB2 (Rho related BTB domain containing 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Salas-Vidal et al., 2005
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With rhobtb2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Developmental and epileptic encephalopathy 64 618004
Associated With rhobtb2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000210 BTB/POZ domain
Family IPR001806 Small GTPase
Family IPR003578 Small GTPase Rho
Homologous_superfamily IPR011333 SKP1/BTB/POZ domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Domain Details Per Protein
Protein Length BTB/POZ domain P-loop containing nucleoside triphosphate hydrolase SKP1/BTB/POZ domain superfamily Small GTPase Small GTPase Rho
UniProtKB:B0V1K9 470
UniProtKB:F1QA56 131
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations