Gene
adora1b
- ID
- ZDB-GENE-081105-156
- Name
- adenosine A1 receptor b
- Symbol
- adora1b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled adenosine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled adenosine receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in dendrite; plasma membrane; and synapse. Is expressed in brain. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Menezes et al., 2018
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Adenosine A1 receptor | Adenosine receptor | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like |
|---|---|---|---|---|---|
|
UniProtKB:B0V2S3
|
341 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
adora1b-201
(1)
|
Ensembl | 1,026 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-73I4 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128584 (1) | 1026 nt | ||
| Genomic | GenBank:CT025875 (1) | 128342 nt | ||
| Polypeptide | UniProtKB:B0V2S3 (1) | 341 aa |
- Edirisinghe, S.L., Nikapitiya, C., Dananjaya, S.H.S., Park, J., Kim, D., Choi, D., De Zoysa, M. (2022) Effect of Polydeoxyribonucleotide (PDRN) Treatment on Corneal Wound Healing in Zebrafish (Danio rerio). International Journal of Molecular Sciences. 23(21):
- Gessler, S., Guthmann, C., Schuler, V., Lilienkamp, M., Walz, G., Yakulov, T.A. (2022) Control of Directed Cell Migration after Tubular Cell Injury by Nucleotide Signaling. International Journal of Molecular Sciences. 23(14):
- Whyte-Fagundes, P., Taskina, D., Safarian, N., Zoidl, C., Carlen, P.L., Donaldson, L.W., Zoidl, G.R. (2022) Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling. Communications biology. 5:472
- Wiprich, M.T., Altenhofen, S., Gusso, D., da Rosa Vasques, R., Zanandrea, R., Kist, L.W., Bogo, M.R., Bonan, C.D. (2022) Modulation of adenosine signaling reverses 3-nitropropionic acid-induced bradykinesia and memory impairment in adult zebrafish. Progress in neuro-psychopharmacology & biological psychiatry. 119:110602
- Kowatschew, D., Korsching, S.I. (2021) An ancient adenosine receptor gains olfactory function in bony vertebrates. Genome biology and evolution. 13(9)
- Yang, N.J., Liu, Y.R., Tang, Z.S., Duan, J.A., Yan, Y.F., Song, Z.X., Wang, M.G., Zhang, Y.R., Chang, B.J., Zhao, M.L., Zhao, Y.T. (2021) Poria cum Radix Pini Rescues Barium Chloride-Induced Arrhythmia by Regulating the cGMP-PKG Signalling Pathway Involving ADORA1 in Zebrafish. Frontiers in pharmacology. 12:688746
- Postlethwait, J.H., Farnsworth, D.R., Miller, A.C. (2020) An intestinal cell type in zebrafish is the nexus for the SARS-CoV-2 receptor and the Renin-Angiotensin-Aldosterone System that contributes to COVID-19 comorbidities. ZFIN Direct Data Submission.
- Safarian, N., Whyte-Fagundes, P., Zoidl, C., Grigull, J., Zoidl, G. (2020) Visuomotor deficiency in panx1a knockout zebrafish is linked to dopaminergic signaling. Scientific Reports. 10:9538
- Cruz, F.F., Pereira, T.C.B., Altenhofen, S., da Costa, K.M., Bogo, M.R., Bonan, C.D., Morrone, F.B. (2019) Characterization of the adenosinergic system in a zebrafish embryo radiotherapy model. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 224:108572
- Menezes, F.P., Machado Torresini, F., Nery, L.R., da Silva, R.S. (2018) Transient Disruption of Adenosine Signaling During Embryogenesis Triggers a Pro-epileptic Phenotype in Adult Zebrafish. Molecular neurobiology. 55(8):6547-6557
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