ZFIN is now using GRCz12tu for Genomic Data
Gene
kif5c
- ID
- ZDB-GENE-081105-14
- Name
- kinesin family member 5C
- Symbol
- kif5c Nomenclature History
- Previous Names
-
- si:ch211-157c24.3
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable ATP hydrolysis activity; microtubule binding activity; and plus-end-directed microtubule motor activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to be located in cytoskeleton and dendrite cytoplasm. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in gonad; immature eye; nervous system; otic vesicle; and trigeminal placode. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Orthologous to human KIF5C (kinesin family member 5C).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complex cortical dysplasia with other brain malformations 2 | Alliance | Cortical dysplasia, complex, with other brain malformations 2 | 615282 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019821 | Kinesin motor domain, conserved site |
| Domain | IPR001752 | Kinesin motor domain |
| Family | IPR027640 | Kinesin-like protein |
| Homologous_superfamily | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| Homologous_superfamily | IPR036961 | Kinesin motor domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Kinesin-like protein | Kinesin motor domain | Kinesin motor domain, conserved site | Kinesin motor domain superfamily | P-loop containing nucleoside triphosphate hydrolase |
|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M1NGN8 | InterPro | 985 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers