Gene
pnck
- ID
- ZDB-GENE-081105-127
- Name
- pregnancy up-regulated nonubiquitous CaM kinase
- Symbol
- pnck Nomenclature History
- Previous Names
-
- si:dkey-7i23.2 (1)
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable calcium/calmodulin-dependent protein kinase activity and calmodulin binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm. Orthologous to human PNCK (pregnancy up-regulated nonubiquitous CaM kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Additional Resources | Length | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
---|---|---|---|---|---|---|
UniProtKB:A0A8N7URA4 | InterPro | 333 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
Relationship | Marker Type | Marker | Accession Numbers | Citations |
---|---|---|---|---|
Contained in | BAC | DKEY-7I23 | ZFIN Curated Data |
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Type | Accession # | Sequence | Length (nt/aa) | Analysis |
---|---|---|---|---|
RNA | RefSeq:XM_690776 (1) | 1530 nt | ||
Genomic | GenBank:BX284664 (1) | 228202 nt | ||
Polypeptide | UniProtKB:A0A8N7URA4 (1) | 333 aa |
- Ding, Q., Weng, Y., Li, Y., Lin, W., Lin, X., Lin, T., Yang, H., Xu, W., Wang, J., Ying, H., Qiu, S. (2024) Inhibition of PNCK inflames tumor microenvironment and sensitizes head and neck squamous cell carcinoma to immune checkpoint inhibitors. Journal for immunotherapy of cancer. 12(10):
- Chen, X., Weng, Y., Li, Y., Fu, W., Huang, Z., Pan, Y., Hong, W., Lin, W., Lin, X., Qiu, S. (2022) Upregulation of PNCK Promotes Metastasis and Angiogenesis via Activating NF-κB/VEGF Pathway in Nasopharyngeal Carcinoma. Journal of oncology. 2022:8541582
- Cardoso, J.C., Bergqvist, C.A., Felix, R.C., Larhammar, D. (2016) Corticotropin-releasing hormone family evolution: five ancestral genes remain in some lineages. Journal of molecular endocrinology. 57(1):73-86
- Lagman, D., Ocampo Daza, D., Widmark, J., Abalo, X.M., Sundström, G., and Larhammar, D. (2013) The vertebrate ancestral repertoire of visual opsins, transducin alpha subunits and oxytocin/vasopressin receptors was established by duplication of their shared genomic region in the two rounds of early vertebrate genome duplications. BMC Evolutionary Biology. 13:238
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